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Gene Review

csrC  -  ncRNA

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3858, IS198, JWR0214, psrA21, ryiB, ...
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Disease relevance of csrC


High impact information on csrC

  • Polyadenylation promotes the degradation of a regulatory RNA that inhibits the replication of bacterial plasmids and may play a similar role in the degradation of mRNA [6].
  • The OxyS regulatory RNA represses rpoS translation and binds the Hfq (HF-I) protein [7].
  • The OxyS regulatory RNA integrates the adaptive response to hydrogen peroxide with other cellular stress responses and protects against DNA damage [7].
  • To evaluate this interpretation, we examine here how inhibitors affect the stabilities of two untranslated RNAs, i.e., an engineered lacZ mRNA lacking a ribosome binding site, and a small regulatory RNA, RNAI [8].
  • The SraD-mediated decay of ompA mRNA depends on Hfq and in vitro studies revealed that Hfq facilitates binding of the regulatory RNA to the translational initiation region of the messenger [9].

Biological context of csrC

  • The agr locus comprises two operons that express a quorum-sensing system from the P2 promoter and a regulatory RNA molecule from the P3 promoter [10].
  • Regulation of ompA mRNA stability: the role of a small regulatory RNA in growth phase-dependent control [9].
  • The resulting RNA-RNA hybrid permits translation of the replicator protein, but blocks base-pairing with a natural negative regulatory RNA [11].
  • Thus, a membrane-bound regulatory RNA binding protein can potentially interact fast enough with its target within the nascent transcript and cause the transcriptional machinery to proceed, before transcriptional termination would occur [12].
  • We propose several alternative functions for the sra gene product, of which that as a regulatory RNA for gene expression may be the most probable one [13].

Associations of csrC with chemical compounds

  • Results suggest that a regulatory RNA molecule is involved in GacA-GacS-mediated regulation of Phl and HCN production in P. fluorescens F113 [14].
  • By contrast, MBP-ExpR(71) does not bind ahlI (gene for AHL synthase), pel-1 (gene for pectate lyase), or rsmB (gene for regulatory RNA that binds RsmA), nor does ExpR(71) activate expression of these genes [15].
  • Similarly to the previously described RNA regulatory elements for three vitamins (riboflavin, thiamin and cobalamin), purine and methionine regulons, this regulatory RNA structure is highly conserved on the sequence and structural levels [16].

Other interactions of csrC


Analytical, diagnostic and therapeutic context of csrC


  1. A novel sRNA component of the carbon storage regulatory system of Escherichia coli. Weilbacher, T., Suzuki, K., Dubey, A.K., Wang, X., Gudapaty, S., Morozov, I., Baker, C.S., Georgellis, D., Babitzke, P., Romeo, T. Mol. Microbiol. (2003) [Pubmed]
  2. Characterization of two novel regulatory genes affecting Salmonella invasion gene expression. Altier, C., Suyemoto, M., Ruiz, A.I., Burnham, K.D., Maurer, R. Mol. Microbiol. (2000) [Pubmed]
  3. The small untranslated RNA SR1 from the Bacillus subtilis genome is involved in the regulation of arginine catabolism. Heidrich, N., Chinali, A., Gerth, U., Brantl, S. Mol. Microbiol. (2006) [Pubmed]
  4. Functional analysis of the internal translation initiation site of foot-and-mouth disease virus. Kühn, R., Luz, N., Beck, E. J. Virol. (1990) [Pubmed]
  5. Probing the structure of RNAIII, the Staphylococcus aureus agr regulatory RNA, and identification of the RNA domain involved in repression of protein A expression. Benito, Y., Kolb, F.A., Romby, P., Lina, G., Etienne, J., Vandenesch, F. RNA (2000) [Pubmed]
  6. Polyadenylation of mRNA in prokaryotes. Sarkar, N. Annu. Rev. Biochem. (1997) [Pubmed]
  7. The OxyS regulatory RNA represses rpoS translation and binds the Hfq (HF-I) protein. Zhang, A., Altuvia, S., Tiwari, A., Argaman, L., Hengge-Aronis, R., Storz, G. EMBO J. (1998) [Pubmed]
  8. Translation inhibitors stabilize Escherichia coli mRNAs independently of ribosome protection. Lopez, P.J., Marchand, I., Yarchuk, O., Dreyfus, M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  9. Regulation of ompA mRNA stability: the role of a small regulatory RNA in growth phase-dependent control. Rasmussen, A.A., Eriksen, M., Gilany, K., Udesen, C., Franch, T., Petersen, C., Valentin-Hansen, P. Mol. Microbiol. (2005) [Pubmed]
  10. Characterization of the SarA virulence gene regulator of Staphylococcus aureus. Rechtin, T.M., Gillaspy, A.F., Schumacher, M.A., Brennan, R.G., Smeltzer, M.S., Hurlburt, B.K. Mol. Microbiol. (1999) [Pubmed]
  11. Combinatorial selection of a small RNA that induces amplification of IncFII plasmids in Escherichia coli. Ferber, M.J., Maher, L.J. J. Mol. Biol. (1998) [Pubmed]
  12. Efficient transcriptional antitermination from the Escherichia coli cytoplasmic membrane. Görke, B., Rak, B. J. Mol. Biol. (2001) [Pubmed]
  13. Discovery of a rhizobial RNA that is essential for symbiotic root nodule development. Ebeling, S., Kündig, C., Hennecke, H. J. Bacteriol. (1991) [Pubmed]
  14. A regulatory RNA (PrrB RNA) modulates expression of secondary metabolite genes in Pseudomonas fluorescens F113. Aarons, S., Abbas, A., Adams, C., Fenton, A., O'Gara, F. J. Bacteriol. (2000) [Pubmed]
  15. ExpR, a LuxR homolog of Erwinia carotovora subsp. carotovora, activates transcription of rsmA, which specifies a global regulatory RNA-binding protein. Cui, Y., Chatterjee, A., Hasegawa, H., Dixit, V., Leigh, N., Chatterjee, A.K. J. Bacteriol. (2005) [Pubmed]
  16. Regulation of lysine biosynthesis and transport genes in bacteria: yet another RNA riboswitch? Rodionov, D.A., Vitreschak, A.G., Mironov, A.A., Gelfand, M.S. Nucleic Acids Res. (2003) [Pubmed]
  17. Identification of CsrC and characterization of its role in epithelial cell invasion in Salmonella enterica serovar Typhimurium. Fortune, D.R., Suyemoto, M., Altier, C. Infect. Immun. (2006) [Pubmed]
  18. Regulation of RpoS by a novel small RNA: the characterization of RprA. Majdalani, N., Chen, S., Murrow, J., St John, K., Gottesman, S. Mol. Microbiol. (2001) [Pubmed]
  19. Constitutive activation of the Escherichia coli Pho regulon upregulates rpoS translation in an Hfq-dependent fashion. Ruiz, N., Silhavy, T.J. J. Bacteriol. (2003) [Pubmed]
  20. Effects of the two-component system comprising GacA and GacS of Erwinia carotovora subsp. carotovora on the production of global regulatory rsmB RNA, extracellular enzymes, and harpinEcc. Cui, Y., Chatterjee, A., Chatterjee, A.K. Mol. Plant Microbe Interact. (2001) [Pubmed]
  21. The Yersinia pestis gcvB gene encodes two small regulatory RNA molecules. McArthur, S.D., Pulvermacher, S.C., Stauffer, G.V. BMC Microbiol. (2006) [Pubmed]
  22. In situ detection of Escherichia coli cells containing ColE1-related plasmids by hybridization to regulatory RNA II. Juretschko, S., Schönhuber, W., Kulakauskas, S., Ehrlich, D.S., Schleifer, K.H., Amann, R. Syst. Appl. Microbiol. (1999) [Pubmed]
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