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Gene Review:

IGHD5-12 - immunoglobulin heavy diversity 5-12

Homo sapiens

Synonyms: DK1, IGHD512

Krangel, M.S. et al., Mebrahtu, Y.B. et al., Yoo, S.K. et al., McCully, J.D. et al., Mattson, D.H. et al.

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Disease relevance of IGHD5-12

Detection of a specific toxicity was demonstrated by simply immobilizing the bioluminescent bacteria, DK1, which increased bioluminescence in the presence of oxidative damage in the cells [1].
The 35- to 50-kilobase DNA fragments were ligated to the cosmid vector pCV108 and packaged into Escherichia coli DK1 [2].

High impact information on IGHD5-12

Comparative structural analysis of HLA-A2 antigens distinguishable by cytotoxic T lymphocytes. II. Variant DK1: evidence for a discrete CTL recognition region [3].
DNA sequences of the genes that encode the CTL-defined HLA-A2 variants M7 and DK1 [4].

Analytical, diagnostic and therapeutic context of IGHD5-12

In this study we utilize double-label tryptic peptide comparisons performed by both reverse-phase HPLC and cation exchange chromatography, in conjunction with conventional and microsequence analysis, to characterize the HLA-A2 heavy chains derived from variant DK1 [3].
The isolates, NLB-271 and NLB-271-IA, were characterized by cellulose acetate electrophoresis (CAE) using 20 enzyme systems and by Southern analysis using 2 deoxyribonucleic acid (DNA) probes (pDK10 and pDK20) from a Dakar strain of L. major (MHOM/SN/00/DK1) and a third probe, p7-059 from L. infantum strain ITMAP-263 [5].

References

Fabrication of a bio-MEMS based cell-chip for toxicity monitoring. Yoo, S.K., Lee, J.H., Yun, S.S., Gu, M.B., Lee, J.H. Biosensors & bioelectronics (2007) [Pubmed]
Construction of cosmid genomic libraries for the normal and myopathic Syrian hamsters. McCully, J.D., Jandreski, M.A., Liew, J., Sole, M.J., Liew, C.C. Biochem. Cell Biol. (1987) [Pubmed]
Comparative structural analysis of HLA-A2 antigens distinguishable by cytotoxic T lymphocytes. II. Variant DK1: evidence for a discrete CTL recognition region. Krangel, M.S., Biddison, W.E., Strominger, J.L. J. Immunol. (1983) [Pubmed]
DNA sequences of the genes that encode the CTL-defined HLA-A2 variants M7 and DK1. Mattson, D.H., Handy, D.E., Bradley, D.A., Coligan, J.E., Cowan, E.P., Biddison, W.E. Immunogenetics (1987) [Pubmed]
Human cutaneous leishmaniasis caused by Leishmania donovani s.l. in Kenya. Mebrahtu, Y.B., Van Eys, G., Guizani, I., Lawyer, P.G., Pamba, H., Koech, D., Roberts, C., Perkins, P.V., Were, J.B., Hendricks, L.D. Trans. R. Soc. Trop. Med. Hyg. (1993) [Pubmed]

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