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GPR33  -  G protein-coupled receptor 33...

Homo sapiens

 
 
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High impact information on GPR33

  • GPR33 is an orphan chemoattractant GPCR that was previously identified as a pseudogene in humans [1].
  • In contrast, the Arg(3.50) to Gly mutation found in hamster GPR33 inactivates the receptor and may have contributed to pseudogenization of this gene in this species [2].
  • Our study also reveals GPR33 as a new example illustrating missense mutations as a first step in the pseudogenization process [2].
  • The deduced amino acid sequence of GPR33 shares 30-35% identity with members of the chemoattractant receptor family and 36% identity with the receptor encoded by GPR32 [3].
  • Through fluorescence in situ hybridization and physical mapping of YACs, both GPR32 and psi GPR32 were mapped to chromosomal 19, region q13.3, while psi GPR33 was mapped to chromosome 14q12 [3].
 

Analytical, diagnostic and therapeutic context of GPR33

  • Sequence analysis of GPR33 from Asian house mice revealed the polymorphic existence of Arg(3.50) and His(3.50) alleles in wild-trapped populations, further supporting the functional equivalence of both allelic variants [2].

References

  1. The rise and fall of the chemoattractant receptor GPR33. Römpler, H., Schulz, A., Pitra, C., Coop, G., Przeworski, M., Pääbo, S., Schöneberg, T. J. Biol. Chem. (2005) [Pubmed]
  2. Functional consequences of naturally occurring DRY motif variants in the mammalian chemoattractant receptor GPR33. Römpler, H., Yu, H.T., Arnold, A., Orth, A., Schöneberg, T. Genomics (2006) [Pubmed]
  3. Cloning genes encoding receptors related to chemoattractant receptors. Marchese, A., Nguyen, T., Malik, P., Xu, S., Cheng, R., Xie, Z., Heng, H.H., George, S.R., Kolakowski, L.F., O'Dowd, B.F. Genomics (1998) [Pubmed]
 
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