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Gene Review:

HCG22 - HLA complex group 22

Homo sapiens

Synonyms: FLJ37114, G2, PBMUCL2, Panbronchiolitis-related mucin-like protein 2, Protein PBMUCL2

Chen, C.D. et al., Nair, R.P. et al.

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High impact information on HCG22

Comparison of sequence of the two risk haplotypes identified a 298-kb region of homology, extending from just telomeric of HLA-B to the HCG22 gene, which was flanked by clearly nonhomologous regions [1].
Patients with HCG15 < 150 mIU/ml but HCG22/HCG15 ratio > or = 15, still had a 90% chance of normal pregnancy [2].

Analytical, diagnostic and therapeutic context of HCG22

We conclude that a single HCG15 determination combined with the ratio of HCG22 to HCG15 has a higher diagnostic accuracy for prediction of pregnancy outcome than either analysis alone [2].

References

Sequence and Haplotype Analysis Supports HLA-C as the Psoriasis Susceptibility 1 Gene. Nair, R.P., Stuart, P.E., Nistor, I., Hiremagalore, R., Chia, N.V., Jenisch, S., Weichenthal, M., Abecasis, G.R., Lim, H.W., Christophers, E., Voorhees, J.J., Elder, J.T. Am. J. Hum. Genet. (2006) [Pubmed]
Paired human chorionic gonadotrophin determinations for the prediction of pregnancy outcome in assisted reproduction. Chen, C.D., Ho, H.N., Wu, M.Y., Chao, K.H., Chen, S.U., Yang, Y.S. Hum. Reprod. (1997) [Pubmed]

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