Gene Review:
HLA-B - major histocompatibility complex, class I, B
Homo sapiens
Synonyms:
AS, HLAB, SPDA1
van den Elsen,
van der Stoep,
Viëtor,
Wilson,
van Zutphen,
Gobin,
Ahmad,
Wallace,
James,
Neville,
Bunce,
Mulcahy-Hawes,
Armuzzi,
Crawshaw,
Fortune,
Walton,
Stanford,
Welsh,
Marshall,
Jewell,
Hetherington,
Hughes,
Mosteller,
Shortino,
Baker,
Spreen,
Lai,
Davies,
Handley,
Dow,
Fling,
Stocum,
Bowman,
Thurmond,
Roses,
Glas,
Martin,
Brünnler,
Kopp,
Folwaczny,
Weiss,
Albert,
Styles,
Hoppe,
Klitz,
Vichinsky,
Lubin,
Trachtenberg,
Snyder,
Wang,
Waring,
Ginder,
Prasad,
Kernan,
Heller,
O'Reilly,
Yang,
Hurks,
Metzelaar-Blok,
Mulder,
Claas,
Jager,
- DNA typing for HLA-A and HLA-B identifies disparities between patients and unrelated donors matched by HLA-A and HLA-B serology and HLA-DRB1. Prasad, V.K., Kernan, N.A., Heller, G., O'Reilly, R.J., Yang, S.Y. Blood (1999)
- Genome sequencing analysis of the 1.8 Mb entire human MHC class I region. Shiina, T., Tamiya, G., Oka, A., Takishima, N., Inoko, H. Immunol. Rev. (1999)
- Loss of HLA haplotype and B locus down-regulation in melanoma cell lines. Marincola, F.M., Shamamian, P., Alexander, R.B., Gnarra, J.R., Turetskaya, R.L., Nedospasov, S.A., Simonis, T.B., Taubenberger, J.K., Yannelli, J., Mixon, A. J. Immunol. (1994)
- Locus-specific transcriptional control of HLA genes. Soong, T.W., Hui, K.M. J. Immunol. (1992)
- Association of MHC Class I chain-related A (MIC-A) gene polymorphism with Type I diabetes. Gambelunghe, G., Ghaderi, M., Cosentino, A., Falorni, A., Brunetti, P., Falorni, A., Sanjeevi, C.B. Diabetologia (2000)
- Identification of a telomeric boundary of the HLA region with potential for predisposition to human narcolepsy. Miyagawa, T., Hohjoh, H., Honda, Y., Juji, T., Tokunaga, K. Immunogenetics (2000)
- Frequency of HLA-A and B alleles in early and late-onset Alzheimer's disease. Middleton, D., Mawhinney, H., Curran, M.D., Edwardson, J.A., Perry, R., McKeith, I., Morris, C., Ince, P.G., Neill, D. Neurosci. Lett. (1999)
- Hepatitis B antigen and antibody in heroin users. Blanck, R.R., Ream, N., Conrad, M. Am. J. Gastroenterol. (1979)
- Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Martin, M.P., Gao, X., Lee, J.H., Nelson, G.W., Detels, R., Goedert, J.J., Buchbinder, S., Hoots, K., Vlahov, D., Trowsdale, J., Wilson, M., O'Brien, S.J., Carrington, M. Nat. Genet. (2002)
- Pretransplantation blood transfusion revisited. van Twuyver, E., Mooijaart, R.J., ten Berge, I.J., van der Horst, A.R., Wilmink, J.M., Kast, W.M., Melief, C.J., de Waal, L.P. N. Engl. J. Med. (1991)
- Relation between skin cancer and HLA antigens in renal-transplant recipients. Bouwes Bavinck, J.N., Vermeer, B.J., van der Woude, F.J., Vandenbroucke, J.P., Schreuder, G.M., Thorogood, J., Persijn, G.G., Claas, F.H. N. Engl. J. Med. (1991)
- The benefit of exchanging donor kidneys among transplant centers. Opelz, G. N. Engl. J. Med. (1988)
- Long-term follow-up in London Transplant Group recipients of cadaver renal allografts. The influence of HLA matching on transplant outcome. Festenstein, H., Doyle, P., Holmes, J. N. Engl. J. Med. (1986)
- Bf and C4 phenotypes in patients with psoriasis. Wyatt, R.J., Wang, C., Hudson, E.C., Jones, R.M., Noah, P.W., Rosenberg, E.W. Acta dermato-venereologica. Supplementum. (1989)
- Allogeneic bone-marrow transplantation in infantile malignant osteopetrosis. Sieff, C.A., Chessells, J.M., Levinsky, R.J., Pritchard, J., Rogers, D.W., Casey, A., Muller, K., Hall, C.M. Lancet (1983)
- Genetic variations in HLA-B region and hypersensitivity reactions to abacavir. Hetherington, S., Hughes, A.R., Mosteller, M., Shortino, D., Baker, K.L., Spreen, W., Lai, E., Davies, K., Handley, A., Dow, D.J., Fling, M.E., Stocum, M., Bowman, C., Thurmond, L.M., Roses, A.D. Lancet (2002)
- Inverse correlation between expression of HLA-B and c-myc in uveal melanoma. Blom, D.J., Mooy, C.M., Luyten, G.P., Kerkvliet, S., Ouwerkerk, I., Zwinderman, A.H., Schrier, P.I., Jager, M.J. J. Pathol. (1997)
- Genomic organization of a polymorphic duplicated region centromeric of HLA-B. Leelayuwat, C., Abraham, L.J., Tabarias, H., Christiansen, F.T., Dawkins, R.L. Immunogenetics (1992)
- Genetic mapping of the 21-hydroxylase-deficiency gene within the HLA linkage group. Levine, L.S., Zachmann, M., New, M.I., Prader, A., Pollack, M.S., O'Neill, G.J., Yang, S.Y., Oberfield, S.E., Dupont, B. N. Engl. J. Med. (1978)
- Class I-like HLA genes map telomeric to the HLA-A2 locus in human cells. Orr, H.T., DeMars, R. Nature (1983)
- Unusual HLA-B alleles in two tribes of Brazilian Indians. Belich, M.P., Madrigal, J.A., Hildebrand, W.H., Zemmour, J., Williams, R.C., Luz, R., Petzl-Erler, M.L., Parham, P. Nature (1992)
- Isolation and N-terminal amino acid sequence of membrane-bound human HLA-A and HLA-B antigens. Bridgen, J., Snary, D., Crumpton, M.J. Nature (1976)
- A new cluster of genes within the human major histocompatibility complex. Spies, T., Blanck, G., Bresnahan, M., Sands, J., Strominger, J.L. Science (1989)
- CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA-A, HLA-B, and HLA-C allotypes. Phillips, J.H., Chang, C., Mattson, J., Gumperz, J.E., Parham, P., Lanier, L.L. Immunity (1996)
- Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C. Fry, A.M., Lanier, L.L., Weiss, A. J. Exp. Med. (1996)
- Cytotoxic T cell recognition of an endogenous class I HLA peptide presented by a class II HLA molecule. Chen, B.P., Madrigal, A., Parham, P. J. Exp. Med. (1990)
- Expression of HLA class I molecules and the transporter associated with antigen processing in hepatocellular carcinoma. Kurokohchi, K., Carrington, M., Mann, D.L., Simonis, T.B., Alexander-Miller, M.A., Feinstone, S.M., Akatsuka, T., Berzofsky, J.A. Hepatology (1996)
- Recognition of nonclassical HLA class I antigens by gamma delta T cells during pregnancy. Barakonyi, A., Kovacs, K.T., Miko, E., Szereday, L., Varga, P., Szekeres-Bartho, J. J. Immunol. (2002)
- The D0 domain of KIR3D acts as a major histocompatibility complex class I binding enhancer. Khakoo, S.I., Geller, R., Shin, S., Jenkins, J.A., Parham, P. J. Exp. Med. (2002)
- Extended major histocompatibility complex haplotypes in type I diabetes mellitus. Raum, D., Awdeh, Z., Yunis, E.J., Alper, C.A., Gabbay, K.H. J. Clin. Invest. (1984)
- The origin of the very variable haemolytic activities of the common human complement component C4 allotypes including C4-A6. Dodds, A.W., Law, S.K., Porter, R.R. EMBO J. (1985)
- Extended HLA/complement allele haplotypes: evidence for T/t-like complex in man. Awdeh, Z.L., Raum, D., Yunis, E.J., Alper, C.A. Proc. Natl. Acad. Sci. U.S.A. (1983)
- HLA-E surface expression depends on binding of TAP-dependent peptides derived from certain HLA class I signal sequences. Lee, N., Goodlett, D.R., Ishitani, A., Marquardt, H., Geraghty, D.E. J. Immunol. (1998)
- Mapping the HLA association in Behçet's disease: a role for tumor necrosis factor polymorphisms? Ahmad, T., Wallace, G.R., James, T., Neville, M., Bunce, M., Mulcahy-Hawes, K., Armuzzi, A., Crawshaw, J., Fortune, F., Walton, R., Stanford, M.R., Welsh, K.I., Marshall, S.E., Jewell, D.P. Arthritis Rheum. (2003)
- Functional promoter modules can be detected by formal models independent of overall nucleotide sequence similarity. Klingenhoff, A., Frech, K., Quandt, K., Werner, T. Bioinformatics (1999)
- HLA-B*1303: a new example of poor correlation between serology and structure. Balas, A., García-Sánchez, F., Vicario, J.L. Hum. Immunol. (1996)
- MICA, MICB and C1_4_1 polymorphism in Crohn's disease and ulcerative colitis. Glas, J., Martin, K., Brünnler, G., Kopp, R., Folwaczny, C., Weiss, E.H., Albert, E.D. Tissue Antigens (2001)
- Identification of CCAAT displacement protein (CDP/cut) as a locus-specific repressor of major histocompatibility complex gene expression in human tumor cells. Snyder, S.R., Wang, J., Waring, J.F., Ginder, G.D. J. Biol. Chem. (2001)
- Methylation status and transcriptional expression of the MHC class I loci in human trophoblast cells from term placenta. Guillaudeux, T., Rodriguez, A.M., Girr, M., Mallet, V., Ellis, S.A., Sargent, I.L., Fauchet, R., Alsat, E., Le Bouteiller, P. J. Immunol. (1995)
- The natural killer cell-mediated killing of autologous dendritic cells is confined to a cell subset expressing CD94/NKG2A, but lacking inhibitory killer Ig-like receptors. Della Chiesa, M., Vitale, M., Carlomagno, S., Ferlazzo, G., Moretta, L., Moretta, A. Eur. J. Immunol. (2003)
- Lack of CIITA expression is central to the absence of antigen presentation functions of trophoblast cells and is caused by methylation of the IFN-gamma inducible promoter (PIV) of CIITA. van den Elsen, P.J., van der Stoep, N., Viëtor, H.E., Wilson, L., van Zutphen, M., Gobin, S.J. Hum. Immunol. (2000)
- High frequency of allele-specific down-regulation of HLA class I expression in uveal melanoma cell lines. Hurks, H.M., Metzelaar-Blok, J.A., Mulder, A., Claas, F.H., Jager, M.J. Int. J. Cancer (2000)
- High expression of HLA-A2 on an oral squamous cell carcinoma with down-regulated transporter for antigen presentation. Matsui, M., Ikeda , M., Akatsuka, T. Biochem. Biophys. Res. Commun. (2001)
- Assembly and maturation of HLA-A and HLA-B antigens in vivo. Krangel, M.S., Orr, H.T., Strominger, J.L. Cell (1979)
- The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells. Cohen, G.B., Gandhi, R.T., Davis, D.M., Mandelboim, O., Chen, B.K., Strominger, J.L., Baltimore, D. Immunity (1999)
- Identification of a novel MHC class I gene, Mamu-AG, expressed in the placenta of a primate with an inactivated G locus. Boyson, J.E., Iwanaga, K.K., Golos, T.G., Watkins, D.I. J. Immunol. (1997)
- Different NK cell surface phenotypes defined by the DX9 antibody are due to KIR3DL1 gene polymorphism. Gardiner, C.M., Guethlein, L.A., Shilling, H.G., Pando, M., Carr, W.H., Rajalingam, R., Vilches, C., Parham, P. J. Immunol. (2001)
- Evidence for HLA-related susceptibility for stroke in children with sickle cell disease. Styles, L.A., Hoppe, C., Klitz, W., Vichinsky, E., Lubin, B., Trachtenberg, E. Blood (2000)
- Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes. D'Andrea, A., Chang, C., Franz-Bacon, K., McClanahan, T., Phillips, J.H., Lanier, L.L. J. Immunol. (1995)
- Alloantibody-mediated class I signal transduction in endothelial cells and smooth muscle cells: enhancement by IFN-gamma and TNF-alpha. Bian, H., Reed, E.F. J. Immunol. (1999)
- Fractionation of membrane proteins on phenylboronic acid-agarose. Williams, G.T., Johnstone, A.P., Dean, P.D. Biochem. J. (1982)