Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

TRBV6-1 - T cell receptor beta variable 6-1

Homo sapiens

Synonyms: TCRBV13S3, TCRBV6S1, TRBV61

Barron, K.S. et al., Brzezinski, J.L. et al., Epplen, C. et al., Gomolka, M. et al., Epplen, C. et al.

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High impact information on TRBV6-1

Furthermore, distinct linkage disequilibria of TCRBV6S1/TCRBV6S3 elements in patients and control subjects strongly suggested an additional risk factor in the TCRBV region for DRB1*15+ individuals [1].
A novel polymorphism in the pseudogene TCRBV5S5 combines with TCRBV6S1 to define three haplotypes [2].
In addition, we provide evidence for linkage disequilibrium between TCRBV5S5P and the TCRBV6S1 gene [2].
For TCRBV6S1 and TCRBV6S7, this profile reflects a diallelic protein polymorphism that correlates exactly with the length of the intronic repeats [3].
The human T-cell receptor variable gene segment TCRBV6S1 has two null alleles [4].

Biological context of TRBV6-1

The extent of polymorphism in TCRBV6S1 was examined by screening 203 individuals of diverse ethnic backgrounds by using SSCP [4].

Other interactions of TRBV6-1

Six T cell receptor (TCR) markers for the CD3D, TCRDVAJ, TEA, TCRBV6S1, BV6S3, BV6S7 and BV13S2 genes were analysed [5].

References

Genetic predisposition to multiple sclerosis as revealed by immunoprinting. Epplen, C., Jäckel, S., Santos, E.J., D'Souza, M., Poehlau, D., Dotzauer, B., Sindern, E., Haupts, M., Rüde, K.P., Weber, F., Stöver, J., Poser, S., Gehler, W., Malin, J.P., Przuntek, H., Epplen, J.T. Ann. Neurol. (1997) [Pubmed]
A novel polymorphism in the pseudogene TCRBV5S5 combines with TCRBV6S1 to define three haplotypes. Brzezinski, J.L., Glass, D.N., Choi, E. Genes Immun. (2001) [Pubmed]
Selected di- and tetranucleotide microsatellites from chromosomes 7, 12, 14, and Y in various Eurasian populations. Gomolka, M., Hundrieser, J., Nürnberg, P., Roewer, L., Epplen, J.T., Epplen, C. Hum. Genet. (1994) [Pubmed]
The human T-cell receptor variable gene segment TCRBV6S1 has two null alleles. Barron, K.S., Robinson, M.A. Hum. Immunol. (1994) [Pubmed]
Immunoprinting excludes many potential susceptibility genes as predisposing to early onset pauciarticular juvenile chronic arthritis except HLA class II and TNF. Epplen, C., Rumpf, H., Albert, E., Haas, P., Truckenbrodt, H., Epplen, J.T. Eur. J. Immunogenet. (1995) [Pubmed]

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