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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Linkage Disequilibrium

 
 
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Disease relevance of Linkage Disequilibrium

 

Psychiatry related information on Linkage Disequilibrium

 

High impact information on Linkage Disequilibrium

 

Chemical compound and disease context of Linkage Disequilibrium

 

Biological context of Linkage Disequilibrium

  • Using fine-mapping based on linkage disequilibrium in North African inbred families, we identified a short ancestral haplotype on chromosome 12q13 (<1 cM), sequenced a BAC contig encompassing the triple-A minimal region and identified a novel gene (AAAS) encoding a protein of 547 amino acids that is mutant in affected individuals [19].
  • DTD maps to distal chromosome 5q and, based on linkage disequilibrium studies in the Finnish population, we had previously predicted that the DTD gene should lie about 64 kb away from the CSF1R locus [20].
  • Direct hybridization analysis of the point mutation using a specific oligonucleotide probe demonstrated that this mutation is also in linkage disequilibrium with RFLP haplotype 2 alleles that make up about 20% of mutant PAH genes [21].
  • It has been difficult to identify the precise MHC genes associated with infection and autoimmunity, mainly because of the strong linkage disequilibrium over the region [22].
  • In this study, we describe three novel intron 1 SNPs, and, together with the coding SNP haplotypes, the data suggest the presence of distinct ancestral haplotypes for HSCR and sporadic MTC in linkage disequilibrium with a putative founding susceptibility locus/loci [23].
 

Anatomical context of Linkage Disequilibrium

 

Associations of Linkage Disequilibrium with chemical compounds

 

Gene context of Linkage Disequilibrium

  • The zone of linkage disequilibrium is flanked by the i97 locus, positioned 30 kb proximal to i82, and the HLA-F gene, found 250 kb distal to HLA-A, markers of which display no significant association with HFE [34].
  • This low level of recombination contributes to the unusually broad region of linkage disequilibrium found with hh [35].
  • Furthermore, the expanded sample yielded a sharp peak of evidence for linkage disequilibrium that spanned approximately 170 kb and that was centered 100 kb telomeric to HLA-C [36].
  • Here we present the results of a search for a region that exhibits linkage disequilibrium with the disorder, under the assumption that identification of such a region may provide an alternative method of narrowing down the location of WRN, the gene responsible for WS [37].
  • Characterization of associations between polymorphic sites located throughout the approximately 200-400-kb variable-length region spanning RNU2-BRCA1 reveals nearly complete linkage disequilibrium [38].
 

Analytical, diagnostic and therapeutic context of Linkage Disequilibrium

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