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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TRAJ1  -  T cell receptor alpha joining 1 (non...

Homo sapiens

 
 
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Disease relevance of TRAJ1

  • A 14-year experience with timed repetitive ankle jerk (TRAJ) testing provides fundamental insights into diabetic neuropathy (DN), both its diagnosis and treatment [1].
 

High impact information on TRAJ1

  • A complete genomic region of 131.2 kb including the swine T-cell receptor alpha/delta constant region (TRAC/TRDC) and joining segments (TRAJ/TRDJ) was sequenced [2].
  • This article illustrates the utilization of SAS-TRAJ mixture modeling to characterize variations in SUD symptom trajectories to define phenotypes [3].
  • Prolongation of TRAJ responses were elicited from 41% of overt diabetics and from 27% and 30% of patients with decreased glucose tolerance demonstrated by morning or afternoon testing, respectively [1].
 

Analytical, diagnostic and therapeutic context of TRAJ1

  • Advantages of TRAJ include ease of performance, relative economy of the equipment, reproducibility of results, and a parameter that encompasses the entire reflex arc [1].

References

  1. Timed repetitive ankle jerk responses in early diabetic neuropathy. Roberts, H.J. South. Med. J. (1982) [Pubmed]
  2. Genomic structure around joining segments and constant regions of swine T-cell receptor alpha/delta (TRA/TRD) locus. Uenishi, H., Hiraiwa, H., Yamamoto, R., Yasue, H., Takagaki, Y., Shiina, T., Kikkawa, E., Inoko, H., Awata, T. Immunology (2003) [Pubmed]
  3. Substance use disorder trajectory classes: diachronic integration of onset age, severity, and course. Clark, D.B., Jones, B.L., Wood, D.S., Cornelius, J.R. Addictive behaviors. (2006) [Pubmed]
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