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MeSH Review

Diabetic Neuropathies

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Disease relevance of Diabetic Neuropathies


Psychiatry related information on Diabetic Neuropathies

  • Witness the differences in the histopathological picture of neuropathy in patients with IDDM and NIDDM despite similar durations and severity of diabetes, the apparent influence of age and gender on the appearance of early neuropathy in patients with IDDM, and the association of alcohol consumption with diabetic neuropathy [6].
  • Increased radical production, leading to the formation of lipid-derived reactive carbonyl species, such as malondialdehyde (MDA), acrolein, and glyoxal, is a characteristic aspect of age-related diseases like Alzheimer's disease or diabetic polyneuropathy [7].

High impact information on Diabetic Neuropathies


Chemical compound and disease context of Diabetic Neuropathies


Biological context of Diabetic Neuropathies


Anatomical context of Diabetic Neuropathies


Gene context of Diabetic Neuropathies


Analytical, diagnostic and therapeutic context of Diabetic Neuropathies


  1. Epinephrine secretion, hypoglycemia unawareness, and diabetic autonomic neuropathy. Hoeldtke, R.D., Boden, G. Ann. Intern. Med. (1994) [Pubmed]
  2. Diabetic peripheral neuropathies. Harati, Y. Ann. Intern. Med. (1987) [Pubmed]
  3. The neurotransmitter N-acetylaspartylglutamate in models of pain, ALS, diabetic neuropathy, CNS injury and schizophrenia. Neale, J.H., Olszewski, R.T., Gehl, L.M., Wroblewska, B., Bzdega, T. Trends Pharmacol. Sci. (2005) [Pubmed]
  4. Nerve biopsy findings in different patterns of proximal diabetic neuropathy. Said, G., Goulon-Goeau, C., Lacroix, C., Moulonguet, A. Ann. Neurol. (1994) [Pubmed]
  5. 9-Alpha-fluorohydrocortisone in the treatment of postural hypotension in diabetic autonomic neuropathy. Campbell, I.W., Ewing, D.J., Clarke, B.F. Diabetes (1975) [Pubmed]
  6. Pathogenesis of diabetic neuropathy: role of altered phosphoinositide metabolism. Greene, D.A., Lattimer-Greene, S., Sima, A.A. Critical reviews in neurobiology. (1989) [Pubmed]
  7. Immunochemical crossreactivity of antibodies specific for "advanced glycation endproducts" with "advanced lipoxidation endproducts". Richter, T., Münch, G., Lüth, H.J., Arendt, T., Kientsch-Engel, R., Stahl, P., Fengler, D., Kuhla, B. Neurobiol. Aging (2005) [Pubmed]
  8. Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. Max, M.B., Lynch, S.A., Muir, J., Shoaf, S.E., Smoller, B., Dubner, R. N. Engl. J. Med. (1992) [Pubmed]
  9. Topical capsaicin in the treatment of painful diabetic neuropathy. Levy, D.M., Abraham, R.R., Tomlinson, D.R. N. Engl. J. Med. (1991) [Pubmed]
  10. Regeneration and repair of myelinated fibers in sural-nerve biopsy specimens from patients with diabetic neuropathy treated with sorbinil. Sima, A.A., Bril, V., Nathaniel, V., McEwen, T.A., Brown, M.B., Lattimer, S.A., Greene, D.A. N. Engl. J. Med. (1988) [Pubmed]
  11. Nerve glucose, fructose, sorbitol, myo-inositol, and fiber degeneration and regeneration in diabetic neuropathy. Dyck, P.J., Zimmerman, B.R., Vilen, T.H., Minnerath, S.R., Karnes, J.L., Yao, J.K., Poduslo, J.F. N. Engl. J. Med. (1988) [Pubmed]
  12. Treatment of painful diabetic neuropathy with topical capsaicin. Ross, D.R., Varipapa, R.J. N. Engl. J. Med. (1989) [Pubmed]
  13. Metabolic and cardiovascular responses to epinephrine in diabetic autonomic neuropathy. Hilsted, J., Richter, E., Madsbad, S., Tronier, B., Christensen, N.J., Hildebrandt, P., Damkjaer, M., Galbo, H. N. Engl. J. Med. (1987) [Pubmed]
  14. Gabapentin for painful diabetic neuropathy. Margolis, K. JAMA (1999) [Pubmed]
  15. Treatment of painful diabetic neuropathy with trazodone. Khurana, R.C. JAMA (1983) [Pubmed]
  16. Oxidative stress and antioxidant defense in relation to the severity of diabetic polyneuropathy and cardiovascular autonomic neuropathy. Ziegler, D., Sohr, C.G., Nourooz-Zadeh, J. Diabetes Care (2004) [Pubmed]
  17. Gastric myoelectrical activity in patients with diabetes. Role of glucose control and autonomic nerve function. Kawagishi, T., Nishizawa, Y., Emoto, M., Maekawa, K., Okuno, Y., Taniwaki, H., Inaba, M., Ishimura, E., Morii, H. Diabetes Care (1997) [Pubmed]
  18. Pyridoxine and pyridoxamine inhibits superoxide radicals and prevents lipid peroxidation, protein glycosylation, and (Na+ + K+)-ATPase activity reduction in high glucose-treated human erythrocytes. Jain, S.K., Lim, G. Free Radic. Biol. Med. (2001) [Pubmed]
  19. Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes. Rudofsky, G., Reismann, P., Witte, S., Humpert, P.M., Isermann, B., Chavakis, T., Tafel, J., Nosikov, V.V., Hamann, A., Nawroth, P., Bierhaus, A. Diabetes Care (2004) [Pubmed]
  20. Myenteric plexus in streptozotocin-treated rats. Neurochemical and histochemical evidence for diabetic neuropathy in the gut. Lincoln, J., Bokor, J.T., Crowe, R., Griffith, S.G., Haven, A.J., Burnstock, G. Gastroenterology (1984) [Pubmed]
  21. Enhanced activation of axonally transported stress-activated protein kinases in peripheral nerve in diabetic neuropathy is prevented by neurotrophin-3. Middlemas, A., Delcroix, J.D., Sayers, N.M., Tomlinson, D.R., Fernyhough, P. Brain (2003) [Pubmed]
  22. Thrombomodulin deficiency in human diabetic nerve microvasculature. Hafer-Macko, C.E., Ivey, F.M., Gyure, K.A., Sorkin, J.D., Macko, R.F. Diabetes (2002) [Pubmed]
  23. Endoneurial microvessels in human diabetic neuropathy. Endothelial cell dysjunction and lack of treatment effect by aldose reductase inhibitor. Sima, A.A., Nathaniel, V., Prashar, A., Bril, V., Greene, D.A. Diabetes (1991) [Pubmed]
  24. Effect of cilostazol on experimental diabetic neuropathy in the rat. Kihara, M., Schmelzer, J.D., Low, P.A. Diabetologia (1995) [Pubmed]
  25. Elevated spinal cyclooxygenase and prostaglandin release during hyperalgesia in diabetic rats. Freshwater, J.D., Svensson, C.I., Malmberg, A.B., Calcutt, N.A. Diabetes (2002) [Pubmed]
  26. Protection against glucose-induced neuronal death by NAAG and GCP II inhibition is regulated by mGluR3. Berent-Spillson, A., Robinson, A.M., Golovoy, D., Slusher, B., Rojas, C., Russell, J.W. J. Neurochem. (2004) [Pubmed]
  27. Selective decrease in axonal nerve growth factor and insulin-like growth factor I immunoreactivity in axonopathies of unknown etiology. Fressinaud, C., Jean, I., Dubas, F. Acta Neuropathol. (2003) [Pubmed]
  28. Characterization of a novel aldose reductase inhibitor, TAT, and its effects on streptozotocin-induced diabetic neuropathy in rats. Inukai, S., Agata, M., Sato, M., Naitou, A., Matsukawa, H., Goto, M. Jpn. J. Pharmacol. (1993) [Pubmed]
  29. Dissection of metabolic, vascular, and nerve conduction interrelationships in experimental diabetic neuropathy by cyclooxygenase inhibition and acetyl-L-carnitine administration. Pop-Busui, R., Marinescu, V., Van Huysen, C., Li, F., Sullivan, K., Greene, D.A., Larkin, D., Stevens, M.J. Diabetes (2002) [Pubmed]
  30. Comparison of the effects of ascorbyl gamma-linolenic acid and gamma-linolenic acid in the correction of neurovascular deficits in diabetic rats. Cameron, N.E., Cotter, M.A. Diabetologia (1996) [Pubmed]
  31. Erythromycin induces supranormal gall bladder contraction in diabetic autonomic neuropathy. Catnach, S.M., Ballinger, A.B., Stevens, M., Fairclough, P.D., Trembath, R.C., Drury, P.L., Watkins, P.J. Gut (1993) [Pubmed]
  32. Noninvasive assessment of cardiac diabetic neuropathy by carbon-11 hydroxyephedrine and positron emission tomography. Allman, K.C., Stevens, M.J., Wieland, D.M., Hutchins, G.D., Wolfe, E.R., Greene, D.A., Schwaiger, M. J. Am. Coll. Cardiol. (1993) [Pubmed]
  33. Treatment of chronic painful diabetic neuropathy with isosorbide dinitrate spray: a double-blind placebo-controlled cross-over study. Yuen, K.C., Baker, N.R., Rayman, G. Diabetes Care (2002) [Pubmed]
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