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Gene Review:

gyrB - DNA gyrase, subunit B (type II topoisomerase)

Acinetobacter sp. ADP1

Yamamoto, S. et al., Vila, J. et al., La Scola, B. et al., Yamamoto, S. et al.

La Scola, Gundi, Khamis, Raoult, Yamamoto, Bouvet, Harayama, Yamamoto, Harayama,

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Disease relevance of gyrB

Phylogenetic structures of the genus Acinetobacter based on gyrB sequences: comparison with the grouping by DNA-DNA hybridization [1].

High impact information on gyrB

Although it is possible that mutations in other locations of the gyrA gene, the gyrB gene, or in other genes may also contribute to the modulation of the MIC level, our results suggest that a gyrA mutation at Ser-83 is associated with quinolone resistance in A. baumannii [2].
A phylogenetic tree constructed using these sequences was supported by bootstrap values higher than those obtained with 16S rRNA or the gyrB or recA gene [3].
The phylogenetic relationships of 49 Acinetobacter strains, 46 of which have previously been classified into 18 genomic species by DNA-DNA hybridization studies, were investigated using the nucleotide sequence of gyrB, the structural gene for the DNA gyrase B subunit [1].
The gyrB sequence homology among these Acinetobacter strains ranged from 69.6 to 99.7% [4].

References

Phylogenetic structures of the genus Acinetobacter based on gyrB sequences: comparison with the grouping by DNA-DNA hybridization. Yamamoto, S., Bouvet, P.J., Harayama, S. Int. J. Syst. Bacteriol. (1999) [Pubmed]
Mutation in the gyrA gene of quinolone-resistant clinical isolates of Acinetobacter baumannii. Vila, J., Ruiz, J., Goñi, P., Marcos, A., Jimenez de Anta, T. Antimicrob. Agents Chemother. (1995) [Pubmed]
Sequencing of the rpoB gene and flanking spacers for molecular identification of Acinetobacter species. La Scola, B., Gundi, V.A., Khamis, A., Raoult, D. J. Clin. Microbiol. (2006) [Pubmed]
Phylogenetic analysis of Acinetobacter strains based on the nucleotide sequences of gyrB genes and on the amino acid sequences of their products. Yamamoto, S., Harayama, S. Int. J. Syst. Bacteriol. (1996) [Pubmed]

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