Disease relevance of gyrA

• Mutation in the gyrA gene of quinolone-resistant clinical isolates of Acinetobacter baumannii [1].

High impact information on gyrA

• Moreover, the mechanisms of resistance to some beta-lactam antibiotics may be associated with the presence of a chromosomal cephalosporinase, AmpC, and the resistance to quinolones related to mutations in the gyrA and parC genes [2].
• Although it is possible that mutations in other locations of the gyrA gene, the gyrB gene, or in other genes may also contribute to the modulation of the MIC level, our results suggest that a gyrA mutation at Ser-83 is associated with quinolone resistance in A. baumannii [1].
• Our studies highlight the conserved sequences in the quinolone resistance-determining region of the gyrA gene from A. baumannii and other bacteria [1].
• Novel gyrA and parC point mutations in two strains of Acinetobacter baumannii resistant to ciprofloxacin [3].
• Mutations in both gyrA and parC were necessary for resistance to moxifloxacin in most isolates of A. baumannii [4].

Biological context of gyrA

• The gyrA and parC genes were sequenced and the adeB gene examined by real-time reverse transcription PCR (RT-PCR) [5].

Associations of gyrA with chemical compounds

• The objective of this study was to analyse an array of ciprofloxacin and norfloxacin derivatives in order to determine those with good activity against bacteria that already present fluoroquinolone resistance associated with mutations in the gyrA and/or parC genes [6].
• Single mutations in both the gyrA and parC genes at codons Ser-83 and Ser-80, respectively, were found in ciprofloxacin- and moxifloxacin-resistant isolates [4].
• Therefore, clinafloxacin shows good activity against strains carrying a single mutation in the gyrA gene, and hence a second mutation is required for the microorganism to express resistance [7].

Analytical, diagnostic and therapeutic context of gyrA

• PCR analysis was used to detect chromosomal mutations in the gyrA and parC genes [4].

References