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Gene Review:

alkM - terminal alkane-1-monooxygenase

Acinetobacter sp. ADP1

Ratajczak, A. et al., Luz, A.P. et al., Ratajczak, A. et al.

Luz, Pellizari, Whyte, Greer,

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Disease relevance of alkM

Alkane hydroxylase from Acinetobacter sp. strain ADP1 is encoded by alkM and belongs to a new family of bacterial integral-membrane hydrocarbon hydroxylases [1].
Specific primers and probes targeting alkane monooxygenase genes were derived from Pseudomonas putida ATCC 29347 (Pp alkB), Rhodococcus sp. strain Q15 (Rh alkB1, Rh alkB2), and Acinetobacter sp. ADP-1 (Ac alkM) [2].

High impact information on alkM

In contrast, the two other ORFs, alkR and alkM, are essential for growth on alkanes as sole carbon sources. alkR encodes a polypeptide with extensive homology to AraC-XyIS-like transcriptional regulators [1].
It is located next to alkM, which encodes the terminal alkane hydroxylase, but is in the opposite orientation [1].
Products of alkane hydroxylase activity like 1-dodecanol prevent induction of alkM expression. alkM is expressed only in stationary phase, suggesting its dependence on at least one other regulatory mechanism [3].

References

Alkane hydroxylase from Acinetobacter sp. strain ADP1 is encoded by alkM and belongs to a new family of bacterial integral-membrane hydrocarbon hydroxylases. Ratajczak, A., Geissdörfer, W., Hillen, W. Appl. Environ. Microbiol. (1998) [Pubmed]
A survey of indigenous microbial hydrocarbon degradation genes in soils from Antarctica and Brazil. Luz, A.P., Pellizari, V.H., Whyte, L.G., Greer, C.W. Can. J. Microbiol. (2004) [Pubmed]
Expression of alkane hydroxylase from Acinetobacter sp. Strain ADP1 is induced by a broad range of n-alkanes and requires the transcriptional activator AlkR. Ratajczak, A., Geissdörfer, W., Hillen, W. J. Bacteriol. (1998) [Pubmed]

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