The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

benA  -  benzoate 1,2-dioxygenase alpha subunit

Acinetobacter sp. ADP1

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of benA

 

High impact information on benA

  • In relation to CatM, CatM(V158M) increased cis,cis-muconate-dependent transcription of benA but decreased that of catB [2].
  • However, three point mutations independently increased CatM-activated benA transcription and enabled growth on benzoate without BenM [2].
  • In contrast, cis,cis-muconate was required with CatM(R156H) to activate unusually high benA expression [2].
  • These substitutions affected regulation of benA differently than that of catB, another CatM-regulated gene involved in benzoate catabolism [2].
  • The benM gene is immediately upstream of, and divergently transcribed from, benA, and a possible DNA binding site for BenM was identified between the two coding regions [3].
 

Biological context of benA

  • The mph-operon and downstream ORFs, ORF9 and ORF10, sharing high identities to benM and benA, which encode ben-operon regulatory protein and benzoate 1,2-dioxygenase alpha subunit respectively, are separated by ORF8, whose function is unknown [1].

References

 
WikiGenes - Universities