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Gene Review

benA  -  benzoate 1,2-dioxygenase alpha subunit

Acinetobacter sp. ADP1

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Disease relevance of benA


High impact information on benA

  • In relation to CatM, CatM(V158M) increased cis,cis-muconate-dependent transcription of benA but decreased that of catB [2].
  • However, three point mutations independently increased CatM-activated benA transcription and enabled growth on benzoate without BenM [2].
  • In contrast, cis,cis-muconate was required with CatM(R156H) to activate unusually high benA expression [2].
  • These substitutions affected regulation of benA differently than that of catB, another CatM-regulated gene involved in benzoate catabolism [2].
  • The benM gene is immediately upstream of, and divergently transcribed from, benA, and a possible DNA binding site for BenM was identified between the two coding regions [3].

Biological context of benA

  • The mph-operon and downstream ORFs, ORF9 and ORF10, sharing high identities to benM and benA, which encode ben-operon regulatory protein and benzoate 1,2-dioxygenase alpha subunit respectively, are separated by ORF8, whose function is unknown [1].


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