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Gene Review

catB  -  muconate cycloisomerase I

Acinetobacter sp. ADP1

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Disease relevance of catB

  • Mutations in catB, the gene encoding muconate cycloisomerase, activate transcription of the distal ben genes and contribute to a complex regulatory circuit in Acinetobacter sp. strain ADP1 [1].

High impact information on catB

  • In relation to CatM, CatM(V158M) increased cis,cis-muconate-dependent transcription of benA but decreased that of catB [2].
  • Consistent with this model, muconate cylcoisomerase specific activities in cell extracts of benzoate-grown catB mutants were low relative to that of the wild type [1].
  • All of the catB mutations increased cis,cis-muconate-activated ben gene expression in strains lacking BenM [1].
  • In a catM-disrupted strain, BenM was able to induce higher levels of catA expression than catB expression [3].
  • Interestingly, further analysis of the two DNA fragments revealed the locations of the catB and catC genes as well [4].

Biological context of catB

  • A third open reading frame, beginning 123 bp upstream from catB and transcribed divergently from this gene, was designated catM [5].
  • In support of this hypothesis, in vivo methylation protection assays showed that CatM protects two guanines in a dyad 65 nucleotides upstream of the catB transcriptional start site, in a location and pattern typical of LysR-type transcriptional activators [6].
  • Removal of the DNA between the SalI sites created a deletion removing the terminal 35 base pairs of the catB gene, the 300-base-pair catC gene, and about 1.1 kb of the 1.2-kb catE gene [7].
  • Investigating this anomaly, we found that insertional inactivation of catM did not cause the phenotype expected for the disruption of a repressor-encoding gene: in an interposon-generated catM mutant, no cat genes were expressed constitutively, but rather catA and catB were still inducible by muconate [6].

Associations of catB with chemical compounds


  1. Mutations in catB, the gene encoding muconate cycloisomerase, activate transcription of the distal ben genes and contribute to a complex regulatory circuit in Acinetobacter sp. strain ADP1. Cosper, N.J., Collier, L.S., Clark, T.J., Scott, R.A., Neidle, E.L. J. Bacteriol. (2000) [Pubmed]
  2. CatM regulation of the benABCDE operon: functional divergence of two LysR-type paralogs in Acinetobacter baylyi ADP1. Ezezika, O.C., Collier-Hyams, L.S., Dale, H.A., Burk, A.C., Neidle, E.L. Appl. Environ. Microbiol. (2006) [Pubmed]
  3. Regulation of benzoate degradation in Acinetobacter sp. strain ADP1 by BenM, a LysR-type transcriptional activator. Collier, L.S., Gaines, G.L., Neidle, E.L. J. Bacteriol. (1998) [Pubmed]
  4. Cloning and characterization of two catA genes in Acinetobacter lwoffii K24. Kim, S.I., Leem, S.H., Choi, J.S., Chung, Y.H., Kim, S., Park, Y.M., Park, Y.K., Lee, Y.N., Ha, K.S. J. Bacteriol. (1997) [Pubmed]
  5. Characterization of Acinetobacter calcoaceticus catM, a repressor gene homologous in sequence to transcriptional activator genes. Neidle, E.L., Hartnett, C., Ornston, L.N. J. Bacteriol. (1989) [Pubmed]
  6. catM encodes a LysR-type transcriptional activator regulating catechol degradation in Acinetobacter calcoaceticus. Romero-Arroyo, C.E., Schell, M.A., Gaines, G.L., Neidle, E.L. J. Bacteriol. (1995) [Pubmed]
  7. Influence of the catBCE sequence on the phenotypic reversion of a pcaE mutation in Acinetobacter calcoaceticus. Doten, R.C., Gregg, L.A., Ornston, L.N. J. Bacteriol. (1987) [Pubmed]
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