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Gene Review

Hoxd3  -  homeo box D3

Rattus norvegicus

Synonyms: Homeobox protein Hox-D3, Homeobox protein R6, Hoxd-3
 
 
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High impact information on Hoxd3

  • The skeletal alterations seen in vitamin A deficiency are associated with posterior shifts in the mesodermal expression of Hoxa-4, Hoxb-3, Hoxd-3, Hoxd-4, and Hoxa-9 mRNAs, whereas the anterior domains of Hoxb-4 and Cdx2 expression are unaltered [1].
  • Increased sensitivity of glycogen synthesis to phosphorylase-a and impaired expression of the glycogen-targeting protein R6 in hepatocytes from insulin-resistant Zucker fa/fa rats [2].

References

  1. Vitamin A deficiency in the late gastrula stage rat embryo results in a one to two vertebral anteriorization that extends throughout the axial skeleton. Kaiser, M.E., Merrill, R.A., Stein, A.C., Breburda, E., Clagett-Dame, M. Dev. Biol. (2003) [Pubmed]
  2. Increased sensitivity of glycogen synthesis to phosphorylase-a and impaired expression of the glycogen-targeting protein R6 in hepatocytes from insulin-resistant Zucker fa/fa rats. Arden, C., Green, A.R., Hampson, L.J., Aiston, S., Härndahl, L., Greenberg, C.C., Brady, M.J., Freeman, S., Poucher, S.M., Agius, L. FEBS J. (2006) [Pubmed]
 
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