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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

IGKV1-8  -  immunoglobulin kappa variable 1-8

Homo sapiens

Synonyms: IGKV18, L9
 
 
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High impact information on IGKV1-8

  • Extracted deposits from the lymph node of one patient were shown by N-terminal amino acid sequence analysis to belong to the variable-region kappa I (Vkappa I) light chain subgroup, the first reported kappa-LCDD protein encoded by the L9 gene and the first report of an expressed protein related to this gene [1].
  • Inhibitor neutralization experiments using these peptides demonstrated that Arg2320 and Cys2326 or Glu2327 are important for the effect of L9 peptide, since their substitution by glycine reduced its neutralizing effect by 60% to >90%, suggesting that they are crucial for formation of the one of the C2 inhibitor epitopes [2].
 

Associations of IGKV1-8 with chemical compounds

  • Mutants of the L9 peptide were prepared in which each residue from 2315-2330 was sequentially substituted by glycine [2].

References

  1. Tumoral non-amyloidotic monoclonal immunoglobulin light chain deposits ('aggregoma'): presenting feature of B-cell dyscrasia in three cases with immunohistochemical and biochemical analyses. Rostagno, A., Frizzera, G., Ylagan, L., Kumar, A., Ghiso, J., Gallo, G. Br. J. Haematol. (2002) [Pubmed]
  2. Identification of a factor VIII peptide, residues 2315-2330, which neutralizes human factor VIII C2 inhibitor alloantibodies: requirement of Cys2326 and Glu2327 for maximum effect. Nogami, K., Shima, M., Nakai, H., Tanaka, I., Suzuki, H., Morichika, S., Shibata, M., Saenko, E.L., Scandella, D., Giddings, J.C., Yoshioka, A. Br. J. Haematol. (1999) [Pubmed]
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