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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Lymph Nodes

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Disease relevance of Lymph Nodes


Psychiatry related information on Lymph Nodes


High impact information on Lymph Nodes


Chemical compound and disease context of Lymph Nodes


Biological context of Lymph Nodes


Anatomical context of Lymph Nodes


Associations of Lymph Nodes with chemical compounds

  • If antigen was injected with the microbial product lipopolysaccharide, proliferation and migration were enhanced, and two populations of memory cells survived for months: one in the lymph nodes that produced the growth factor interleukin-2, and a larger one in the non-lymphoid tissues that produced the anti-microbial lymphokine interferon-gamma [29].
  • MAdCAM-1 isolated from mesenteric lymph nodes, but not from cultured endothelioma cells, bears N-glycanase-resistant sialic acid-containing carbohydrate which supports adhesion of L-selectin-transfected lymphoid cells under shear [30].
  • Here we show that although Langerhans cells express all four PGE receptor subtypes, their migration to regional lymph nodes was decreased only in EP4-deficient (Ptger4-/-) mice and in wild-type mice treated with an EP4 antagonist [31].
  • Reactivity with MECA 79, an adhesion-blocking mAb that stains HEV in lymph nodes and vessels in chronic inflammatory sites, is also lost from the luminal aspects of HEV [32].
  • At concentrations as low as 4 microM, reserpine profoundly suppressed baseline or antigen-augmented levels of [3H]thymidine incorporation by immune lymph node cells obtained from mice sensitized to the contactant oxazolone [I-LNC(Ox)] [33].

Gene context of Lymph Nodes


Analytical, diagnostic and therapeutic context of Lymph Nodes


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  2. Detection of carcinoembryonic antigen messenger RNA in lymph nodes from patients with colorectal cancer. Bostick, P.J., Hoon, D.S., Cote, R.J. N. Engl. J. Med. (1998) [Pubmed]
  3. Molecular assessment of histopathological staging in squamous-cell carcinoma of the head and neck. Brennan, J.A., Mao, L., Hruban, R.H., Boyle, J.O., Eby, Y.J., Koch, W.M., Goodman, S.N., Sidransky, D. N. Engl. J. Med. (1995) [Pubmed]
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  5. T-lymphocyte subsets in lymph nodes from homosexual men. Modlin, R.L., Meyer, P.R., Hofman, F.M., Mehlmauer, M., Levy, N.B., Lukes, R.J., Parker, J.W., Ammann, A.J., Conant, M.A., Rea, T.H., Taylor, C.R. JAMA (1983) [Pubmed]
  6. T cell development in mice expressing splice variants of the protein tyrosine phosphatase CD45. Kozieradzki, I., Kündig, T., Kishihara, K., Ong, C.J., Chiu, D., Wallace, V.A., Kawai, K., Timms, E., Ionescu, J., Ohashi, P., Marth, J.D., Mak, T.W., Penninger, J.M. J. Immunol. (1997) [Pubmed]
  7. Adrenal hormone modulation of type 1 and type 2 cytokine production by spleen cells: dexamethasone and dehydroepiandrosterone suppress interleukin-2, interleukin-4, and interferon-gamma production in vitro. Moynihan, J.A., Callahan, T.A., Kelley, S.P., Campbell, L.M. Cell. Immunol. (1998) [Pubmed]
  8. Thorotrast-induced ruptured hepatic angiosarcoma. Azodo, M.V., Gutierrez, O.H., Greer, T. Abdominal imaging. (1993) [Pubmed]
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  10. Detection of carcinoembryonic antigen messenger RNA in lymph nodes from patients with colorectal cancer. Merrie, A.E., Yun, K., McCall, J.L. N. Engl. J. Med. (1998) [Pubmed]
  11. Effective surgical adjuvant therapy for high-risk rectal carcinoma. Krook, J.E., Moertel, C.G., Gunderson, L.L., Wieand, H.S., Collins, R.T., Beart, R.W., Kubista, T.P., Poon, M.A., Meyers, W.C., Mailliard, J.A. N. Engl. J. Med. (1991) [Pubmed]
  12. CD44 is the principal cell surface receptor for hyaluronate. Aruffo, A., Stamenkovic, I., Melnick, M., Underhill, C.B., Seed, B. Cell (1990) [Pubmed]
  13. Differential requirement for CD18 in T-helper effector homing. Lee, S.H., Prince, J.E., Rais, M., Kheradmand, F., Shardonofsky, F., Lu, H., Beaudet, A.L., Smith, C.W., Soong, L., Corry, D.B. Nat. Med. (2003) [Pubmed]
  14. Soluble factors in tolerance and contact sensitivity to 2,4-dinitrofluorobenzene in mice. III. Histocompatibility antigens associated with the hapten dinitrophenol serve as target molecules on 2,4-dinitrofluorobenzene-immune T cells for soluble suppressor factor. Moorhead, J.W. J. Exp. Med. (1979) [Pubmed]
  15. CC chemokine receptor 7-dependent and -independent pathways for lymphocyte homing: modulation by FTY720. Henning, G., Ohl, L., Junt, T., Reiterer, P., Brinkmann, V., Nakano, H., Hohenberger, W., Lipp, M., Förster, R. J. Exp. Med. (2001) [Pubmed]
  16. Rat lymphoid cell lines with human T cell leukemia virus production. I. Biological and serological characterization. Tateno, M., Kondo, N., Itoh, T., Chubachi, T., Togashi, T., Yoshiki, T. J. Exp. Med. (1984) [Pubmed]
  17. Intralymphatic administration of liposome-encapsulated drugs to mice: possibility for suppression of the growth of tumor metastases in the lymph nodes. Kaledin, V.I., Matienko, N.A., Nikolin, V.P., Gruntenko, Y.V., Budker, V.G. J. Natl. Cancer Inst. (1981) [Pubmed]
  18. Differentiation and tumorigenicity of human malignant melanocytes in relation to their culture conditions. Aubert, C., Rougé, F., Galindo, J.R. J. Natl. Cancer Inst. (1984) [Pubmed]
  19. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Kong, Y.Y., Yoshida, H., Sarosi, I., Tan, H.L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A.J., Van, G., Itie, A., Khoo, W., Wakeham, A., Dunstan, C.R., Lacey, D.L., Mak, T.W., Boyle, W.J., Penninger, J.M. Nature (1999) [Pubmed]
  20. Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice. Arbonés, M.L., Ord, D.C., Ley, K., Ratech, H., Maynard-Curry, C., Otten, G., Capon, D.J., Tedder, T.F. Immunity (1994) [Pubmed]
  21. A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice. Roths, J.B., Murphy, E.D., Eicher, E.M. J. Exp. Med. (1984) [Pubmed]
  22. CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. Herman, A.E., Freeman, G.J., Mathis, D., Benoist, C. J. Exp. Med. (2004) [Pubmed]
  23. Role of the high affinity immunoglobulin E receptor in bacterial translocation and intestinal inflammation. Dombrowicz, D., Nutten, S., Desreumaux, P., Neut, C., Torpier, G., Peeters, M., Colombel, J.F., Capron, M. J. Exp. Med. (2001) [Pubmed]
  24. A novel serine esterase expressed by cytotoxic T lymphocytes. Pasternack, M.S., Eisen, H.N. Nature (1985) [Pubmed]
  25. Direct evidence for a two-signal mechanism of cytotoxic T-lymphocyte activation. Teh, H.S., Teh, S.J. Nature (1980) [Pubmed]
  26. A chemokine-driven positive feedback loop organizes lymphoid follicles. Ansel, K.M., Ngo, V.N., Hyman, P.L., Luther, S.A., Förster, R., Sedgwick, J.D., Browning, J.L., Lipp, M., Cyster, J.G. Nature (2000) [Pubmed]
  27. Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin. Spertini, O., Kansas, G.S., Munro, J.M., Griffin, J.D., Tedder, T.F. Nature (1991) [Pubmed]
  28. Adhesion through L-selectin requires a threshold hydrodynamic shear. Finger, E.B., Puri, K.D., Alon, R., Lawrence, M.B., von Andrian, U.H., Springer, T.A. Nature (1996) [Pubmed]
  29. Visualizing the generation of memory CD4 T cells in the whole body. Reinhardt, R.L., Khoruts, A., Merica, R., Zell, T., Jenkins, M.K. Nature (2001) [Pubmed]
  30. L-selectin-mediated lymphocyte rolling on MAdCAM-1. Berg, E.L., McEvoy, L.M., Berlin, C., Bargatze, R.F., Butcher, E.C. Nature (1993) [Pubmed]
  31. Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells. Kabashima, K., Sakata, D., Nagamachi, M., Miyachi, Y., Inaba, K., Narumiya, S. Nat. Med. (2003) [Pubmed]
  32. Sulfation of L-selectin ligands by an HEV-restricted sulfotransferase regulates lymphocyte homing to lymph nodes. Hemmerich, S., Bistrup, A., Singer, M.S., van Zante, A., Lee, J.K., Tsay, D., Peters, M., Carminati, J.L., Brennan, T.J., Carver-Moore, K., Leviten, M., Fuentes, M.E., Ruddle, N.H., Rosen, S.D. Immunity (2001) [Pubmed]
  33. Reevaluation of reserpine-induced suppression of contact sensitivity. Evidence that reserpine interferes with T lymphocyte function independently of an effect on mast cells. Mekori, Y.A., Weitzman, G.L., Galli, S.J. J. Exp. Med. (1985) [Pubmed]
  34. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Gunn, M.D., Ngo, V.N., Ansel, K.M., Ekland, E.H., Cyster, J.G., Williams, L.T. Nature (1998) [Pubmed]
  35. Lymph node genesis is induced by signaling through the lymphotoxin beta receptor. Rennert, P.D., James, D., Mackay, F., Browning, J.L., Hochman, P.S. Immunity (1998) [Pubmed]
  36. Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice. Koni, P.A., Sacca, R., Lawton, P., Browning, J.L., Ruddle, N.H., Flavell, R.A. Immunity (1997) [Pubmed]
  37. Interleukin 13 is secreted by and stimulates the growth of Hodgkin and Reed-Sternberg cells. Kapp, U., Yeh, W.C., Patterson, B., Elia, A.J., Kägi, D., Ho, A., Hessel, A., Tipsword, M., Williams, A., Mirtsos, C., Itie, A., Moyle, M., Mak, T.W. J. Exp. Med. (1999) [Pubmed]
  38. Evidence for a mature B cell subpopulation in Peyer's patches of young adult xid mice. Eldridge, J.H., Kiyono, H., Michalek, S.M., McGhee, J.R. J. Exp. Med. (1983) [Pubmed]
  39. Massive upregulation of the Fas ligand in lpr and gld mice: implications for Fas regulation and the graft-versus-host disease-like wasting syndrome. Chu, J.L., Ramos, P., Rosendorff, A., Nikolić-Zugić, J., Lacy, E., Matsuzawa, A., Elkon, K.B. J. Exp. Med. (1995) [Pubmed]
  40. Migratory behavior of lymphocytes with specific reactivity to alloantigens. II. Selective recruitment to lymphoid cell allografts and their draining lymph nodes. Emeson, E.E. J. Exp. Med. (1978) [Pubmed]
  41. Monocyte chemotactic protein 1 regulates oral tolerance induction by inhibition of T helper cell 1-related cytokines. Karpus, W.J., Kennedy, K.J., Kunkel, S.L., Lukacs, N.W. J. Exp. Med. (1998) [Pubmed]
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