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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CHMP4A  -  charged multivesicular body protein 4A

Homo sapiens

Synonyms: C14orf123, CDA04, CHMP4, CHMP4B, CHMP4a, ...
 
 
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High impact information on CHMP4A

  • CHMP4b messages were expressed at higher levels in all 12 tissues tested in comparison with the CHMP4a and CHMP4c transcripts, particularly in heart and skeletal muscle [1].
  • Snf7p (sucrose non-fermenting) and Vps20p (vacuolar protein-sorting) are small coil-coiled proteins involved in yeast MVB (multivesicular body) structure, formation and function [2].
 

Analytical, diagnostic and therapeutic context of CHMP4A

  • Additional immunofluorescence experiments showed that hSnf7-1 recruited cytosolic AIP1 to the Snf7-induced vacuolar-like structures [2].

References

  1. CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms. Katoh, K., Shibata, H., Hatta, K., Maki, M. Arch. Biochem. Biophys. (2004) [Pubmed]
  2. Structure and function of human Vps20 and Snf7 proteins. Peck, J.W., Bowden, E.T., Burbelo, P.D. Biochem. J. (2004) [Pubmed]
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