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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RANGRF  -  RAN guanine nucleotide release factor

Homo sapiens

Synonyms: HSPC165, HSPC236, MDS5, MOG1, RANGNRF, ...
 
 
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High impact information on RANGNRF

  • On the remaining members of the family (two structural genomics targets, and a protein involved in the photosystem II complex in higher plants) we identified novel binding sites with little correspondence to those on Mog1p [1].
  • Mog1 is an evolutionarily conserved nuclear protein that binds RanGTP and stimulates guanine nucleotide release, suggesting Mog1 regulates the nuclear transport functions of Ran [2].
  • In permeabilized cells, nuclear import of Mog1 is independent of exogenously added factors, and is inhibited by wheat germ agglutinin, indicating that translocation of Mog1 involves physical interactions with the nuclear pore complex [2].

References

  1. Insights into Protein-Protein Interfaces using a Bayesian Network Prediction Method. Bradford, J.R., Needham, C.J., Bulpitt, A.J., Westhead, D.R. J. Mol. Biol. (2006) [Pubmed]
  2. Identification of a conserved loop in Mog1 that releases GTP from Ran. Steggerda, S.M., Paschal, B.M. Traffic (2001) [Pubmed]
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