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Gene Review

Ran  -  RAN, member RAS oncogene family

Mus musculus

Synonyms: GTP-binding nuclear protein Ran, GTPase Ran, Ras-like protein TC4, Ras-related nuclear protein, Rasl2-8
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Disease relevance of Ran


High impact information on Ran


Biological context of Ran


Anatomical context of Ran


Associations of Ran with chemical compounds

  • The involvement of Ran GTPase in lipopolysaccharide endotoxin-induced responses [13].
  • The Ran GTPase Mediates Chromatin Signaling to Control Cortical Polarity during Polar Body Extrusion in Mouse Oocytes [14].
  • To identify genes involved in the commitment of MEL cells to differentiate, we screened a cDNA library constructed from HMBA-induced cells by differential hybridization and isolated GTPase Ran as a down-regulated gene [2].

Regulatory relationships of Ran

  • At the nonpermissive temperature, importin-beta was exported from the nucleus of these cells, even when RanGAP1, a GTPase-activating protein for Ran, was co-injected [12].

Other interactions of Ran

  • The results indicate that the novel nuclear protein Spa-1, with a potentially active Ran GAP domain, severely hampers the mitogen-induced cell cycle progression when abnormally and/or prematurely expressed [8].
  • Like other small GTPases, Ran appears to function as a switch: Ran-GTP and Ran-GDP levels are regulated both by guanine nucleotide exchange factors and GTPase activating proteins, and Ran-GTP and Ran-GDP interact differentially with one or more effectors [15].
  • Consistently, a mutant importin-beta deficient in Ran binding can deliver its cargo up to the nucleoplasmic side of the NPC [3].

Analytical, diagnostic and therapeutic context of Ran


  1. Ran GTPase expression during early development of the mouse embryo. López-Casas, P.P., López-Fernández, L.A., Krimer, D.B., del Mazo, J. Mech. Dev. (2002) [Pubmed]
  2. Differential expression of Ran GTPase during HMBA-induced differentiation in murine erythroleukemia cells. Vanegas, N., García-Sacristán, A., López-Fernández, L.A., Párraga, M., del Mazo, J., Hernández, P., Schvartzman, J.B., Krimer, D.B. Leuk. Res. (2003) [Pubmed]
  3. Identification of different roles for RanGDP and RanGTP in nuclear protein import. Görlich, D., Panté, N., Kutay, U., Aebi, U., Bischoff, F.R. EMBO J. (1996) [Pubmed]
  4. Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoprotein. Peloponese, J.M., Haller, K., Miyazato, A., Jeang, K.T. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  5. A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3). Hong, D.H., Pawlyk, B.S., Shang, J., Sandberg, M.A., Berson, E.L., Li, T. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  6. Cell cycle-dependent localization and possible roles of the small GTPase Ran in mouse oocyte maturation, fertilization and early cleavage. Cao, Y.K., Zhong, Z.S., Chen, D.Y., Zhang, G.X., Schatten, H., Sun, Q.Y. Reproduction (2005) [Pubmed]
  7. An ATP-dependent activity that releases RanGDP from NTF2. Yamada, M., Mattaj, I.W., Yoneda, Y. J. Biol. Chem. (2004) [Pubmed]
  8. Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression. Hattori, M., Tsukamoto, N., Nur-e-Kamal, M.S., Rubinfeld, B., Iwai, K., Kubota, H., Maruta, H., Minato, N. Mol. Cell. Biol. (1995) [Pubmed]
  9. Mammalian RanBP1 regulates centrosome cohesion during mitosis. Di Fiore, B., Ciciarello, M., Mangiacasale, R., Palena, A., Tassin, A.M., Cundari, E., Lavia, P. J. Cell. Sci. (2003) [Pubmed]
  10. Developmental regulation of expression of Ran/M1 and Ran/M2 isoforms of Ran-GTPase in mouse testis. López-Casas, P.P., López-Fernández, L.A., Párraga, M., Krimer, D.B., del Mazo, J. Int. J. Dev. Biol. (2003) [Pubmed]
  11. Regulated Ran-binding protein 1 activity is required for organization and function of the mitotic spindle in mammalian cells in vivo. Guarguaglini, G., Renzi, L., D'Ottavio, F., Di Fiore, B., Casenghi, M., Cundari, E., Lavia, P. Cell Growth Differ. (2000) [Pubmed]
  12. beta-subunit of nuclear pore-targeting complex (importin-beta) can be exported from the nucleus in a Ran-independent manner. Kose, S., Imamoto, N., Tachibana, T., Yoshida, M., Yoneda, Y. J. Biol. Chem. (1999) [Pubmed]
  13. The involvement of Ran GTPase in lipopolysaccharide endotoxin-induced responses. Zhao, F., Yuan, Q., Sultzer, B.M., Chung, S.W., Wong, P.M. J. Endotoxin Res. (2001) [Pubmed]
  14. The Ran GTPase Mediates Chromatin Signaling to Control Cortical Polarity during Polar Body Extrusion in Mouse Oocytes. Deng, M., Suraneni, P., Schultz, R.M., Li, R. Dev. Cell (2007) [Pubmed]
  15. Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing. Ren, M., Villamarin, A., Shih, A., Coutavas, E., Moore, M.S., LoCurcio, M., Clarke, V., Oppenheim, J.D., D'Eustachio, P., Rush, M.G. Mol. Cell. Biol. (1995) [Pubmed]
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