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Gene Review:

Ggps1 - geranylgeranyl diphosphate synthase 1

Rattus norvegicus

Synonyms: (2E,6E)-farnesyl diphosphate synthase, Crlf3, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Farnesyltranstransferase, ...

Sagami, H. et al., Marrero, P.F. et al.

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High impact information on Ggps1

Comparison of the farnesyl diphosphate (FPP) synthase amino acid sequences from four species with amino acid sequences from the related enzymes hexaprenyl diphosphate synthase and geranylgeranyl diphosphate synthase show the presence of two aspartate rich highly conserved domains [1].
Studies on geranylgeranyl diphosphate synthase from rat liver: specific inhibition by 3-azageranylgeranyl diphosphate [2].
Specific inhibition of geranylgeranyl diphosphate synthase by VII was also observed in experiments with 100,000g supernatants of rat brain and liver homogenates which contained isopentenyl diphosphate isomerase and prenyltransferases including farnesyl diphosphate synthase as well as geranylgeranyl diphosphate synthase [2].

References

Effects of site-directed mutagenesis of the highly conserved aspartate residues in domain II of farnesyl diphosphate synthase activity. Marrero, P.F., Poulter, C.D., Edwards, P.A. J. Biol. Chem. (1992) [Pubmed]
Studies on geranylgeranyl diphosphate synthase from rat liver: specific inhibition by 3-azageranylgeranyl diphosphate. Sagami, H., Korenaga, T., Ogura, K., Steiger, A., Pyun, H.J., Coates, R.M. Arch. Biochem. Biophys. (1992) [Pubmed]

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AgaP_AGAP006894	Anopheles gambiae str. PEST
AGOS_AEL238C	Ashbya gossypii ATCC 10895
GGPS1	Bos taurus
GGPS1	Canis lupus familiaris
ggps1	Danio rerio
qm	Drosophila melanogaster
GGPS1	Gallus gallus
GGPS1	Homo sapiens
KLLA0E23299g	Kluyveromyces lactis NRRL Y-1140
GGPS1	Macaca mulatta
MGG_00758	Magnaporthe oryzae 70-15
Ggps1	Mus musculus
NCU01427	Neurospora crassa OR74A
GGPS1	Pan troglodytes
BTS1	Saccharomyces cerevisiae S288c
ggps1	Xenopus (Silurana) tropicalis

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