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Gene Review

GGPS1  -  geranylgeranyl diphosphate synthase 1

Homo sapiens

Synonyms: (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Farnesyltranstransferase, GGPP synthase, ...
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Disease relevance of GGPS1


High impact information on GGPS1


Biological context of GGPS1


Anatomical context of GGPS1

  • Geranylgeranyl diphosphate synthase remained soluble in the stroma in a free form and phytoene synthase associated to thylakoid membranes upon import, both as expected [9].
  • During testis development the total GGPS mRNA expression level increased, accompanied by an increase in 1b-type mRNA, the expression level of 1a-type mRNA encoding active GGPS remaining kept unchanged [7].

Associations of GGPS1 with chemical compounds


Other interactions of GGPS1


Analytical, diagnostic and therapeutic context of GGPS1


  1. Human geranylgeranyl diphosphate synthase. cDNA cloning and expression. Kuzuguchi, T., Morita, Y., Sagami, I., Sagami, H., Ogura, K. J. Biol. Chem. (1999) [Pubmed]
  2. The crtE gene in Erwinia herbicola encodes geranylgeranyl diphosphate synthase. Math, S.K., Hearst, J.E., Poulter, C.D. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  3. Formation of monoterpenes in Antirrhinum majus and Clarkia breweri flowers involves heterodimeric geranyl diphosphate synthases. Tholl, D., Kish, C.M., Orlova, I., Sherman, D., Gershenzon, J., Pichersky, E., Dudareva, N. Plant Cell (2004) [Pubmed]
  4. Evaluation of transgenic tomato plants expressing an additional phytoene synthase in a fruit-specific manner. Fraser, P.D., Romer, S., Shipton, C.A., Mills, P.B., Kiano, J.W., Misawa, N., Drake, R.G., Schuch, W., Bramley, P.M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  5. Interaction with the small subunit of geranyl diphosphate synthase modifies the chain length specificity of geranylgeranyl diphosphate synthase to produce geranyl diphosphate. Burke, C., Croteau, R. J. Biol. Chem. (2002) [Pubmed]
  6. Maize cDNAs expressed in endosperm encode functional farnesyl diphosphate synthase with geranylgeranyl diphosphate synthase activity. Cervantes-Cervantes, M., Gallagher, C.E., Zhu, C., Wurtzel, E.T. Plant Physiol. (2006) [Pubmed]
  7. Relationship between intron 4b splicing of the rat geranylgeranyl diphosphate synthase gene and the active enzyme expression level. Matsumura, Y., Kuzuguchi, T., Sagami, H. J. Biochem. (2004) [Pubmed]
  8. A new geranylgeranyl diphosphate synthase gene from Ginkgo biloba, which intermediates the biosynthesis of the key precursor for ginkgolides. Liao, Z., Chen, M., Gong, Y., Guo, L., Tan, Q., Feng, X., Sun, X., Tan, F., Tang, K. DNA Seq. (2004) [Pubmed]
  9. Chloroplast import of four carotenoid biosynthetic enzymes in vitro reveals differential fates prior to membrane binding and oligomeric assembly. Bonk, M., Hoffmann, B., Von Lintig, J., Schledz, M., Al-Babili, S., Hobeika, E., Kleinig, H., Beyer, P. Eur. J. Biochem. (1997) [Pubmed]
  10. Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human. Kainou, T., Kawamura, K., Tanaka, K., Matsuda, H., Kawamukai, M. Biochim. Biophys. Acta (1999) [Pubmed]
  11. Analysis and purification of phosphorylated isoprenoids by reversed-phase HPLC. Zhang, D., Poulter, C.D. Anal. Biochem. (1993) [Pubmed]
  12. Gibberellin biosynthetic pathway in Gibberella fujikuroi: evidence for a gene cluster. Tudzynski, B., Hölter, K. Fungal Genet. Biol. (1998) [Pubmed]
  13. Geranylgeranyl diphosphate synthases from Scoparia dulcis and Croton sublyratus. cDNA cloning, functional expression, and conversion to a farnesyl diphosphate synthase. Kojima, N., Sitthithaworn, W., Viroonchatapan, E., Suh, D.Y., Iwanami, N., Hayashi, T., Sankaw, U. Chem. Pharm. Bull. (2000) [Pubmed]
  14. Geranylgeranyl diphosphate synthase from Scoparia dulcis and Croton sublyratus. Plastid localization and conversion to a farnesyl diphosphate synthase by mutagenesis. Sitthithaworn, W., Kojima, N., Viroonchatapan, E., Suh, D.Y., Iwanami, N., Hayashi, T., Noji, M., Saito, K., Niwa, Y., Sankawa, U. Chem. Pharm. Bull. (2001) [Pubmed]
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