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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Nudc  -  nudC nuclear distribution protein

Rattus norvegicus

Synonyms: Nuclear distribution protein C homolog, Nuclear migration protein nudC, Silg92, c15
 
 
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High impact information on Nudc

  • Clone 15 (c15) was originally identified as a PRL-inducible gene in activated T cells [1].
  • Corresponding [3H]thymidine incorporation experiments show that the maximum level of c15 mRNA expression correlates with the G1/S transition phase of the cell cycle [2].
  • Sequence analysis revealed that the c15 open reading frame contains a potential nuclear localization signal, a very acidic region, and a carboxy-terminal region of 94 amino acids which are 68% identical and 78% similar to the nuclear movement protein, NUDC, found in Aspergillus nidulans [2].
 

Anatomical context of Nudc

  • PRL stimulation of quiescent Nb2 T cells results in the expression of a 1.7-kilobase c15 mRNA, which reaches maximum levels between 8 and 10 h after stimulation [2].

References

  1. A prolactin-inducible T cell gene product is structurally similar to the Aspergillus nidulans nuclear movement protein NUDC. Morris, S.M., Anaya, P., Xiang, X., Morris, N.R., May, G.S., Yu-Lee, L. Mol. Endocrinol. (1997) [Pubmed]
  2. Characterization of a prolactin-inducible gene, clone 15, in T cells. Axtell, S.M., Truong, T.M., O'Neal, K.D., Yu-Lee, L.Y. Mol. Endocrinol. (1995) [Pubmed]
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