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Gene Review

NUDC  -  nudC nuclear distribution protein

Homo sapiens

Synonyms: HNUDC, MNUDC, NPD011, Nuclear distribution protein C homolog, Nuclear migration protein nudC, ...
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Disease relevance of NUDC


High impact information on NUDC


Biological context of NUDC

  • Primers which amplify individual exons of NUDC were developed for mutation analysis [8].
  • We have isolated the human NUDC gene and its two processed pseudogenes [8].
  • NUDC consists of at least 9 exons ranging from 66 bp to 266 bp in size and 8 introns from 92 bp to 2.0 kb in length, and the total genomic region spans about 8 kb [8].
  • These results demonstrate that the LIS-1/NUDC-like proteins of C. elegans represent a link between nuclear positioning, cell division, and neuronal function [9].
  • The human NUDC gene is highly conserved and its predicted amino acid sequence shows 94% identity to mouse NudC and 95% identity to rat NudC [8].

Anatomical context of NUDC

  • Further, a key mitotic enzyme, polo-like kinase, is mislocalized from the centrosomes and the midbody in NudC altered cells [10].
  • In normal human bone marrow, HNUDC protein and mRNA are highly expressed in early myeloid and erythroid precursors and decline as these cells terminally differentiate [3].
  • Immunofluorescence staining of human megakaryocyte cells indicated that hNUDC and Mpl colocalized at all stages of megakaryocyte development [11].
  • Consistent with its expression in individual neurons, a high level of NudC is detected in regions of the embryonic neocortex undergoing extensive neurogenesis as well as neuronal migration [12].
  • We also demonstrated by western blotting that most cell lines express extremely high levels of HNUDC compared to their normal counterparts [13].

Regulatory relationships of NUDC

  • These data demonstrate that HNUDC is highly expressed in normal and malignant human hematopoietic precursors and suggest it is of functional importance in the proliferation of these cells [3].

Other interactions of NUDC


Analytical, diagnostic and therapeutic context of NUDC


  1. A role for Plk1 phosphorylation of NudC in cytokinesis. Zhou, T., Aumais, J.P., Liu, X., Yu-Lee, L.Y., Erikson, R.L. Dev. Cell (2003) [Pubmed]
  2. Inhibition of prostate tumor growth by overexpression of NudC, a microtubule motor-associated protein. Lin, S.H., Nishino, M., Luo, W., Aumais, J.P., Galfione, M., Kuang, J., Yu-Lee, L.Y. Oncogene (2004) [Pubmed]
  3. A homolog of the fungal nuclear migration gene nudC is involved in normal and malignant human hematopoiesis. Miller, B.A., Zhang, M.Y., Gocke, C.D., De Souza, C., Osmani, A.H., Lynch, C., Davies, J., Bell, L., Osmani, S.A. Exp. Hematol. (1999) [Pubmed]
  4. The nuclear migration gene NudC and human hematopoiesis. Gocke, C.D., Reaman, G.H., Stine, C., Zhang, M.Y., Osmani, S.A., Miller, B.A. Leuk. Lymphoma (2000) [Pubmed]
  5. A mammalian NudC-like protein essential for dynein stability and cell viability. Zhou, T., Zimmerman, W., Liu, X., Erikson, R.L. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  6. NudC is required for Plk1 targeting to the kinetochore and chromosome congression. Nishino, M., Kurasawa, Y., Evans, R., Lin, S.H., Brinkley, B.R., Yu-Lee, L.Y. Curr. Biol. (2006) [Pubmed]
  7. The lissencephaly gene product Lis1, a protein involved in neuronal migration, interacts with a nuclear movement protein, NudC. Morris, S.M., Albrecht, U., Reiner, O., Eichele, G., Yu-Lee, L.Y. Curr. Biol. (1998) [Pubmed]
  8. Molecular cloning and characterization of the human NUDC gene. Matsumoto, N., Ledbetter, D.H. Hum. Genet. (1999) [Pubmed]
  9. Evolutionarily conserved nuclear migration genes required for early embryonic development in Caenorhabditis elegans. Dawe, A.L., Caldwell, K.A., Harris, P.M., Morris, N.R., Caldwell, G.A. Dev. Genes Evol. (2001) [Pubmed]
  10. Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis. Aumais, J.P., Williams, S.N., Luo, W., Nishino, M., Caldwell, K.A., Caldwell, G.A., Lin, S.H., Yu-Lee, L.Y. J. Cell. Sci. (2003) [Pubmed]
  11. A microtubule associated protein (hNUDC) binds to the extracellular domain of thrombopoietin receptor (Mpl). Pan, R.M., Yang, Y., Wei, M.X., Yu, X.B., Ge, Y.C., Xu, P. J. Cell. Biochem. (2005) [Pubmed]
  12. NudC associates with Lis1 and the dynein motor at the leading pole of neurons. Aumais, J.P., Tunstead, J.R., McNeil, R.S., Schaar, B.T., McConnell, S.K., Lin, S.H., Clark, G.D., Yu-Lee, L.Y. J. Neurosci. (2001) [Pubmed]
  13. The human homologue of the Aspergillus nuclear migration gene nudC is preferentially expressed in dividing cells and ciliated epithelia. Gocke, C.D., Osmani, S.A., Miller, B.A. Histochem. Cell Biol. (2000) [Pubmed]
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