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Disease relevance of Aspergillus


Psychiatry related information on Aspergillus


High impact information on Aspergillus


Chemical compound and disease context of Aspergillus


Biological context of Aspergillus


Anatomical context of Aspergillus


Associations of Aspergillus with chemical compounds

  • In addition, capu shares both a proline-rich region and a 70-amino-acid domain with a number of other genes, two of which also function in pattern formation, the Saccharomyes cerevisiae BNI1 gene and the Aspergillus FigA gene [28].
  • The Aspergillus nidulans fluG gene is required for production of an extracellular developmental signal and is related to prokaryotic glutamine synthetase I [29].
  • The members of the fungal genus Aspergillus are commonly used for the production of polysaccharide-degrading enzymes [30].
  • A patient with Aspergillus pneumonia was treated with a synergistic combination of amphotericin B and flucytosine [31].
  • Aspergillus fumigatus, growing saprophytically in bronchial mucus, is responsible for most cases, and prednisone, not antifungal agents, is the drug of choice because it controls the immunologic responses of the lung [32].

Gene context of Aspergillus

  • In Aspergillus nidulans, the LIS1 homolog, NUDF, and cytoplasmic dynein are genetically linked and regulate nuclear movements during hyphal growth [33].
  • Nek2 (for NIMA-related kinase 2) is a mammalian cell cycle-regulated kinase structurally related to the mitotic regulator NIMA of Aspergillus nidulans [34].
  • Identification and molecular analysis of a third Aspergillus nidulans alcohol dehydrogenase gene [35].
  • Suppression of the bimC4 mitotic spindle defect by deletion of klpA, a gene encoding a KAR3-related kinesin-like protein in Aspergillus nidulans [36].
  • The sequence and binding specificity of UaY, the specific regulator of the purine utilization pathway in Aspergillus nidulans, suggest an evolutionary relationship with the PPR1 protein of Saccharomyces cerevisiae [37].

Analytical, diagnostic and therapeutic context of Aspergillus


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  2. Therapeutic concentrations of glucocorticoids suppress the antimicrobial activity of human macrophages without impairing their responsiveness to gamma interferon. Schaffner, A. J. Clin. Invest. (1985) [Pubmed]
  3. Amphotericin-resistant aspergillus osteomyelitis controlled by itraconazole. Sachs, M.K., Paluzzi, R.G., Moore, J.H., Fraimow, H.S., Ost, D. Lancet (1990) [Pubmed]
  4. Developmental regulation of the Aspergillus nidulans trpC gene. Yelton, M.M., Hamer, J.E., de Souza, E.R., Mullaney, E.J., Timberlake, W.E. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  5. Fungal metabolic model for human type I hereditary tyrosinaemia. Fernández-Cañón, J.M., Peñalva, M.A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  6. Toxicity and mutagenicity of molds of the Aspergillus glaucus group. Identification of physcion and three related anthraquinones as main toxic constituents from Aspergillus chevalieri. Bachmann, M., Lüthy, J., Schlatter, C. J. Agric. Food Chem. (1979) [Pubmed]
  7. Forum report: issues in the evaluation of diagnostic tests, use of historical controls, and merits of the current multicenter collaborative groups. Bennett, J.E., Kauffman, C., Walsh, T., de Pauw, B., Dismukes, W., Galgiani, J., Glauser, M., Herbrecht, R., Lee, J., Pappas, P., Powers, J., Rex, J., Verweij, P., Viscoli, C. Clin. Infect. Dis. (2003) [Pubmed]
  8. Nucleotide sequence of the triosephosphate isomerase gene from Aspergillus nidulans: implications for a differential loss of introns. McKnight, G.L., O'Hara, P.J., Parker, M.L. Cell (1986) [Pubmed]
  9. The mosaic organization of the apocytochrome b gene of Aspergillus nidulans revealed by DNA sequencing. Waring, R.B., Davies, R.W., Lee, S., Grisi, E., Berks, M.M., Scazzocchio, C. Cell (1981) [Pubmed]
  10. Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Garlanda, C., Hirsch, E., Bozza, S., Salustri, A., De Acetis, M., Nota, R., Maccagno, A., Riva, F., Bottazzi, B., Peri, G., Doni, A., Vago, L., Botto, M., De Santis, R., Carminati, P., Siracusa, G., Altruda, F., Vecchi, A., Romani, L., Mantovani, A. Nature (2002) [Pubmed]
  11. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Ingber, D., Fujita, T., Kishimoto, S., Sudo, K., Kanamaru, T., Brem, H., Folkman, J. Nature (1990) [Pubmed]
  12. A potent nonpeptide cholecystokinin antagonist selective for peripheral tissues isolated from Aspergillus alliaceus. Chang, R.S., Lotti, V.J., Monaghan, R.L., Birnbaum, J., Stapley, E.O., Goetz, M.A., Albers-Schönberg, G., Patchett, A.A., Liesch, J.M., Hensens, O.D. Science (1985) [Pubmed]
  13. Aspergillus galactomannan detection in the diagnosis of invasive aspergillosis in cancer patients. Herbrecht, R., Letscher-Bru, V., Oprea, C., Lioure, B., Waller, J., Campos, F., Villard, O., Liu, K.L., Natarajan-Amé, S., Lutz, P., Dufour, P., Bergerat, J.P., Candolfi, E. J. Clin. Oncol. (2002) [Pubmed]
  14. T cell vaccination in mice with invasive pulmonary aspergillosis. Cenci, E., Mencacci, A., Bacci, A., Bistoni, F., Kurup, V.P., Romani, L. J. Immunol. (2000) [Pubmed]
  15. Cloning and expression in Escherichia coli of the gene encoding Aspergillus flavus urate oxidase. Legoux, R., Delpech, B., Dumont, X., Guillemot, J.C., Ramond, P., Shire, D., Caput, D., Ferrara, P., Loison, G. J. Biol. Chem. (1992) [Pubmed]
  16. IL-13 fusion cytotoxin ameliorates chronic fungal-induced allergic airway disease in mice. Blease, K., Jakubzick, C., Schuh, J.M., Joshi, B.H., Puri, R.K., Hogaboam, C.M. J. Immunol. (2001) [Pubmed]
  17. Development of Aspergillus sinusitis in a patient receiving amphotericin B. Treatment with granulocyte transfusions. Swerdlow, B., Deresinski, S. Am. J. Med. (1984) [Pubmed]
  18. The mitochondrial genome of the fission yeast Schizosaccharomyces pombe: highly homologous introns are inserted at the same position of the otherwise less conserved cox1 genes in Schizosaccharomyces pombe and Aspergillus nidulans. Lang, B.F. EMBO J. (1984) [Pubmed]
  19. Identification and functional analysis of beta-tubulin genes by site specific integrative transformation in Aspergillus nidulans. May, G.S., Gambino, J., Weatherbee, J.A., Morris, N.R. J. Cell Biol. (1985) [Pubmed]
  20. Two S-phase checkpoint systems, one involving the function of both BIME and Tyr15 phosphorylation of p34cdc2, inhibit NIMA and prevent premature mitosis. Ye, X.S., Fincher, R.R., Tang, A., O'Donnell, K., Osmani, S.A. EMBO J. (1996) [Pubmed]
  21. Two different, adjacent and divergent zinc finger binding sites are necessary for CREA-mediated carbon catabolite repression in the proline gene cluster of Aspergillus nidulans. Cubero, B., Scazzocchio, C. EMBO J. (1994) [Pubmed]
  22. Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi. Stoldt, V.R., Sonneborn, A., Leuker, C.E., Ernst, J.F. EMBO J. (1997) [Pubmed]
  23. Evolutionary origins of vertebrate hormones: substances similar to mammalian insulins are native to unicellular eukaryotes. Le Roith, D., Shiloach, J., Roth, J., Lesniak, M.A. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  24. Calmodulin-dependent multifunctional protein kinase in Aspergillus nidulans. Bartelt, D.C., Fidel, S., Farber, L.H., Wolff, D.J., Hammell, R.L. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  25. Hyphal tip extension in Aspergillus nidulans requires the manA gene, which encodes phosphomannose isomerase. Smith, D.J., Payton, M.A. Mol. Cell. Biol. (1994) [Pubmed]
  26. A dendritic cell vaccine against invasive aspergillosis in allogeneic hematopoietic transplantation. Bozza, S., Perruccio, K., Montagnoli, C., Gaziano, R., Bellocchio, S., Burchielli, E., Nkwanyuo, G., Pitzurra, L., Velardi, A., Romani, L. Blood (2003) [Pubmed]
  27. Elimination of Aspergillus infection in allogeneic stem cell transplant recipients with long-term itraconazole prophylaxis: prevention is better than treatment. Winston, D.J., Emmanouilides, C., Bartoni, K., Schiller, G.J., Paquette, R., Territo, M.C. Blood (2004) [Pubmed]
  28. Cappuccino, a Drosophila maternal effect gene required for polarity of the egg and embryo, is related to the vertebrate limb deformity locus. Emmons, S., Phan, H., Calley, J., Chen, W., James, B., Manseau, L. Genes Dev. (1995) [Pubmed]
  29. The Aspergillus nidulans fluG gene is required for production of an extracellular developmental signal and is related to prokaryotic glutamine synthetase I. Lee, B.N., Adams, T.H. Genes Dev. (1994) [Pubmed]
  30. Aspergillus enzymes involved in degradation of plant cell wall polysaccharides. de Vries, R.P., Visser, J. Microbiol. Mol. Biol. Rev. (2001) [Pubmed]
  31. Combined amphotericin B-flucytosine therapy in Aspergillus pneumonia. Codish, S.D., Tobias, J.S., Hannigan, M. JAMA (1979) [Pubmed]
  32. Immunologic aspects of lung diseases and cystic fibrosis. Greenberger, P.A. JAMA (1997) [Pubmed]
  33. NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. Niethammer, M., Smith, D.S., Ayala, R., Peng, J., Ko, J., Lee, M.S., Morabito, M., Tsai, L.H. Neuron (2000) [Pubmed]
  34. C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2. Fry, A.M., Mayor, T., Meraldi, P., Stierhof, Y.D., Tanaka, K., Nigg, E.A. J. Cell Biol. (1998) [Pubmed]
  35. Identification and molecular analysis of a third Aspergillus nidulans alcohol dehydrogenase gene. McKnight, G.L., Kato, H., Upshall, A., Parker, M.D., Saari, G., O'Hara, P.J. EMBO J. (1985) [Pubmed]
  36. Suppression of the bimC4 mitotic spindle defect by deletion of klpA, a gene encoding a KAR3-related kinesin-like protein in Aspergillus nidulans. O'Connell, M.J., Meluh, P.B., Rose, M.D., Morris, N.R. J. Cell Biol. (1993) [Pubmed]
  37. The sequence and binding specificity of UaY, the specific regulator of the purine utilization pathway in Aspergillus nidulans, suggest an evolutionary relationship with the PPR1 protein of Saccharomyces cerevisiae. Suárez, T., de Queiroz, M.V., Oestreicher, N., Scazzocchio, C. EMBO J. (1995) [Pubmed]
  38. Molecular cloning and functional characterization of the pathway-specific regulatory gene nirA, which controls nitrate assimilation in Aspergillus nidulans. Burger, G., Tilburn, J., Scazzocchio, C. Mol. Cell. Biol. (1991) [Pubmed]
  39. Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo. Han, B., Luo, G., Shi, Z.Z., Barrios, R., Atwood, D., Liu, W., Habib, G.M., Sifers, R.N., Corry, D.B., Lieberman, M.W. Am. J. Pathol. (2002) [Pubmed]
  40. Purification and properties of the nuclease inhibitor of Aspergillus oryzae and kinetics of its interaction with crystalline nuclease O. Uozumi, T., Ishino, K., Beppu, T., Arima, K. J. Biol. Chem. (1976) [Pubmed]
  41. Site-directed mutagenesis of nitrate reductase from Aspergillus nidulans. Identification of some essential and some nonessential amino acids among conserved residues. Garde, J., Kinghorn, J.R., Tomsett, A.B. J. Biol. Chem. (1995) [Pubmed]
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