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Gene Review:

ABT1 - activator of basal transcription 1

Homo sapiens

Synonyms: Activator of basal transcription 1, Basal transcriptional activator, hABT1

Oda, T. et al., Norlin, M. et al.

Norlin, Chiang,

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High impact information on ABT1

We recently identified a novel nuclear protein, activator of basal transcription 1 (ABT1), which binds TBP and DNA, and enhances Pol II-directed basal transcription [1].
ABT1-associated protein (ABTAP), a novel nuclear protein conserved from yeast to mammals, represses transcriptional activation by ABT1 [1].
An SREBP-1-responsive region was mapped to a GC-rich sequence in the proximal CYP7B1 promoter, containing binding sites for the basal transcriptional activator Sp1 [2].

References

ABT1-associated protein (ABTAP), a novel nuclear protein conserved from yeast to mammals, represses transcriptional activation by ABT1. Oda, T., Fukuda, A., Hagiwara, H., Masuho, Y., Muramatsu, M.A., Hisatake, K., Yamashita, T. J. Cell. Biochem. (2004) [Pubmed]
Transcriptional regulation of human oxysterol 7alpha-hydroxylase by sterol response element binding protein. Norlin, M., Chiang, J.Y. Biochem. Biophys. Res. Commun. (2004) [Pubmed]

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ABT1	Bos taurus
ABT1	Canis lupus familiaris
abt1	Danio rerio
ABT1	Macaca mulatta
Abt1	Mus musculus
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