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hoxb4a  -  homeobox B4a

Danio rerio

Synonyms: HOX-B4, Homeobox protein Hox-B4a, Homeobox protein Zf-13, Hox-B4, SO:0000704, ...
 
 
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High impact information on hoxb4a

  • At a similar anteroposterior level within the nervous system, expression of the retinoic acid receptor a and hoxb4 genes is delayed and significantly reduced [1].
  • We use mosaic analysis to show that the reduction in hoxb4 expression in the nervous system is a non-cell autonomous effect, reflecting a requirement for retinoic acid signalling from adjacent paraxial mesoderm [1].
  • Transgenic approaches were used to analyze the functions of zebrafish hoxb3a/hoxb4a promoters and enhancer sequences containing regions of homology that were previously identified by comparative genomics [2].

References

  1. The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrain. Begemann, G., Schilling, T.F., Rauch, G.J., Geisler, R., Ingham, P.W. Development (2001) [Pubmed]
  2. Conserved co-regulation and promoter sharing of hoxb3a and hoxb4a in zebrafish. Hadrys, T., Punnamoottil, B., Pieper, M., Kikuta, H., Pezeron, G., Becker, T.S., Prince, V., Baker, R., Rinkwitz, S. Dev. Biol. (2006) [Pubmed]
 
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