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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Tspan17  -  tetraspanin 17

Rattus norvegicus

Synonyms: F-box only protein 23, Fbxo23, GHB-R, Tetraspanin-17, Tspan-17
 
 
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High impact information on Fbxo23

  • Endogenous gamma-aminobutyric acid (GABA)(A) receptor active neurosteroids and the sedative/hypnotic action of gamma-hydroxybutyric acid (GHB): a study in GHB-S (sensitive) and GHB-R (resistant) rat lines [1].
  • Sub-hypnotic doses (7.5 and 12.5 mg/kg, i.p.) of pregnanolone, administered 10 min before GHB, dose-dependently facilitated the expression of GHB-induced LORR in GHB-R male rats [1].
  • These results suggest that the differential sensitivity of GHB-S and GHB-R rats to GHB and baclofen extends to the effects produced by doses of the two drugs which are 5-10 times lower than those for which rats have been selectively bred [2].

References

  1. Endogenous gamma-aminobutyric acid (GABA)(A) receptor active neurosteroids and the sedative/hypnotic action of gamma-hydroxybutyric acid (GHB): a study in GHB-S (sensitive) and GHB-R (resistant) rat lines. Barbaccia, M.L., Carai, M.A., Colombo, G., Lobina, C., Purdy, R.H., Gessa, G.L. Neuropharmacology (2005) [Pubmed]
  2. Different sensitivity to the motor incoordinating effects of gamma-hydroxybutyric acid (GHB) and baclofen in GHB-sensitive and GHB-resistant rats. Lobina, C., Colombo, G., Gessa, G.L., Carai, M.A. Brain Res. (2005) [Pubmed]
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