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Gene Review:

HLA-DPB2 - major histocompatibility complex, class II...

Homo sapiens

Synonyms: DP2B, DPB2, DPbeta2, HLA-DP2B

Dixon, M.J. et al., Grahovac, B. et al., Hanson, I.M. et al., Erlich, H. et al.

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High impact information on HLA-DPB2

Finally, we have demonstrated, by the isolation of overlapping cosmid clones, that the gene is 45 kb centromeric to the HLA-DPB2 locus and oriented with the 3' end toward the MHC [1].
In each of the four species, the DP region consists of four loci arranged in the same order (DPB2 . . . DPA2 . . . DPB1 . . . DPA1) and in the same transcriptional orientation (tail-to-tail) [2].
However, no RNA transcripts for either DP alpha 2 or DP beta 2 could be detected [3].

Analytical, diagnostic and therapeutic context of HLA-DPB2

These were defined by in-situ hybridization as 6p21.31 (by using loci in the HLA complex defined by the probes p45.1DP beta 003/HLA-DPB2 and pRS5.10/HLA class I chain) and 16p13.11 (by using probes pACHF1.3.2/D16S8 and VK45/D16S131) [4].

References

The human alpha 2(XI) collagen gene (COL11A2) maps to the centromeric border of the major histocompatibility complex on chromosome 6. Hanson, I.M., Gorman, P., Lui, V.C., Cheah, K.S., Solomon, E., Trowsdale, J. Genomics (1989) [Pubmed]
Conservative evolution of the Mbc-DP region in anthropoid primates. Grahovac, B., Schönbach, C., Brändle, U., Mayer, W.E., Golubic, M., Figueroa, F., Trowsdale, J., Klein, J. Hum. Immunol. (1993) [Pubmed]
Molecular analysis of HLA class I and class II antigen loss mutants reveals a homozygous deletion of the DR, DQ, and part of the DP region: implications for class II gene order. Erlich, H., Lee, J.S., Petersen, J.W., Bugawan, T., DeMars, R. Hum. Immunol. (1986) [Pubmed]
Association of Treacher Collins syndrome and translocation 6p21.31/16p13.11: exclusion of the locus from these candidate regions. Dixon, M.J., Haan, E., Baker, E., David, D., McKenzie, N., Williamson, R., Mulley, J., Farrall, M., Callen, D. Am. J. Hum. Genet. (1991) [Pubmed]

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