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Gene Review

HLA-DPB1  -  major histocompatibility complex, class II...

Homo sapiens

Synonyms: DPB1, HLA class II histocompatibility antigen, DP beta 1 chain, HLA class II histocompatibility antigen, DP(W4) beta chain, HLA-DP, HLA-DP1B, ...
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Disease relevance of HLA-DPB1


High impact information on HLA-DPB1

  • Disparities in class II HLA alleles of the DRB1, DQA1, DQB1, DPA1, and DPB1 loci were not identified as significant risk factors for acute GVHD or death in the multivariate analysis [6].
  • New HLA-DPB1 alleles generated by interallelic gene conversion detected by analysis of sperm [7].
  • Our results demonstrated that a large fraction of skin-infiltrating lymphocytes, which expressed diverse T cell receptors, were reactive against this single HLA-DPB1 *0501 mismatch and consequently that a single HLA-DP mismatch between BM donor and recipient can activate a strong T cell response in vivo [8].
  • HLA class I antigens were determined serologically, and the DRB1, DQA1, DQB1, and DPB1 genes and the DRB3/4/5 subtypes were determined by high-resolution genotyping [9].
  • Association of HLA-DPB with Hodgkin's disease [10].

Chemical compound and disease context of HLA-DPB1


Biological context of HLA-DPB1


Anatomical context of HLA-DPB1


Associations of HLA-DPB1 with chemical compounds

  • HLA typing was carried out by the PCR-RFLP method, which allowed discrimination of most HLA DQA1, DQB1, DPB1, and DRB alleles [23].
  • Twenty-two out of 25 beryllium-sensitive, non-CBD individuals were found to be carriers of the HLA-DPB1 gene having a substitution of a glutamic acid at position 69 in Exon 2 (Glu69), and a significantly high percentage (24%) were Glu69 homozygotes [24].
  • Associations were sought between the presence of allergic sensitivity to Der p 1, a major allergen from the house dust mite, and the HLA-DPB1 genotype [25].
  • Genetic studies also demonstrated an association of CBD with HLA-DPB1 alleles that contain glutamine at position 69 in up to 97 percent of subjects with CBD but also 30-40 percent of controls [26].
  • DPB1*6001, found in two individuals, contains a single nucleotide change that results in a polar amino acid, asparagine, at residue 65; this position in the beta 1 domain is occupied by a nonpolar amino acid in all other reported DPB1 alleles [27].

Physical interactions of HLA-DPB1

  • Further gel-retardation analysis has demonstrated that hXBP-1 also binds to HLA-DPB X2 but not to other X2 sequences [28].

Regulatory relationships of HLA-DPB1

  • RESULTS: HLA-DPB1*0510 was the the most common allele in patients with RA and healthy controls in Taiwan. There was no significant difference in frequencies of HLA-DPB1 alleles between patients and controls [29].
  • These data suggest that in addition to alleles at the DRB1 and DQB1 loci, polymorphism at the DPB1 locus may also influence IDDM risk [30].

Other interactions of HLA-DPB1

  • We studied 129 patients who underwent marrow transplantation from HLA-A, -B, -DRB, and -DQB matched URDs to determine whether matching for HLA-DPB1 alleles significantly decreased the risk of developing acute GVHD [3].
  • The Mamu-DPA1 gene is invariant and -DPB1 manifests only moderate allelic variation, whereas the HLA-DPA1 gene is oligomorphic and HLA-DPB1 highly polymorphic [31].
  • Analysis of TAP gene polymorphisms will provide better understanding of susceptibility loci in HLA class II-associated disease because TAP genes are located between HLA-DQB1 and HLA-DPB1 loci [32].
  • Retrospective A, B, C, DRB1, DQA1, DQB1 in addition to DPA1 and DPB1 allele matching was performed by molecular techniques [22].
  • DNA-based HLA typing for DRB1, DQB1, and DPB1 was performed on 16 consistently RF--patients with erosive RA [33].

Analytical, diagnostic and therapeutic context of HLA-DPB1


  1. HLA-DPB1 glutamate 69: a genetic marker of beryllium disease. Richeldi, L., Sorrentino, R., Saltini, C. Science (1993) [Pubmed]
  2. HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites. Rossman, M.D., Thompson, B., Frederick, M., Maliarik, M., Iannuzzi, M.C., Rybicki, B.A., Pandey, J.P., Newman, L.S., Magira, E., Beznik-Cizman, B., Monos, D. Am. J. Hum. Genet. (2003) [Pubmed]
  3. The role of HLA-DPB1 disparity in the development of acute graft-versus-host disease following unrelated donor marrow transplantation. Petersdorf, E.W., Smith, A.G., Mickelson, E.M., Longton, G.M., Anasetti, C., Choo, S.Y., Martin, P.J., Hansen, J.A. Blood (1993) [Pubmed]
  4. Graft rejection after unrelated donor hematopoietic stem cell transplantation for thalassemia is associated with nonpermissive HLA-DPB1 disparity in host-versus-graft direction. Fleischhauer, K., Locatelli, F., Zecca, M., Orofino, M.G., Giardini, C., De Stefano, P., Pession, A., Iannone, A.M., Carcassi, C., Zino, E., La Nasa, G. Blood (2006) [Pubmed]
  5. HLA-A and DPB1 loci confer susceptibility to Graves' disease. Dong, R.P., Kimura, A., Okubo, R., Shinagawa, H., Tamai, H., Nishimura, Y., Sasazuki, T. Hum. Immunol. (1992) [Pubmed]
  6. Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor. Japan Marrow Donor Program. Sasazuki, T., Juji, T., Morishima, Y., Kinukawa, N., Kashiwabara, H., Inoko, H., Yoshida, T., Kimura, A., Akaza, T., Kamikawaji, N., Kodera, Y., Takaku, F. N. Engl. J. Med. (1998) [Pubmed]
  7. New HLA-DPB1 alleles generated by interallelic gene conversion detected by analysis of sperm. Zangenberg, G., Huang, M.M., Arnheim, N., Erlich, H. Nat. Genet. (1995) [Pubmed]
  8. Acute graft versus host disease due to T lymphocytes recognizing a single HLA-DPB1*0501 mismatch. Gaschet, J., Lim, A., Liem, L., Vivien, R., Hallet, M.M., Harousseau, J.L., Even, J., Goulmy, E., Bonneville, M., Milpied, N., Vié, H. J. Clin. Invest. (1996) [Pubmed]
  9. Allelic basis for HLA-encoded susceptibility to type 1 autoimmune hepatitis. Strettell, M.D., Donaldson, P.T., Thomson, L.J., Santrach, P.J., Moore, S.B., Czaja, A.J., Williams, R. Gastroenterology (1997) [Pubmed]
  10. Association of HLA-DPB with Hodgkin's disease. Tonks, S., Oza, A.M., Lister, T.A., Bodmer, J.G. Lancet (1992) [Pubmed]
  11. Influence of MHC class II in susceptibility to beryllium sensitization and chronic beryllium disease. Maier, L.A., McGrath, D.S., Sato, H., Lympany, P., Welsh, K., Du Bois, R., Silveira, L., Fontenot, A.P., Sawyer, R.T., Wilcox, E., Newman, L.S. J. Immunol. (2003) [Pubmed]
  12. Molecular analysis of HLA-DPB1 alleles in idiopathic systemic sclerosis patients and uranium miners with systemic sclerosis. Rihs, H.P., Conrad, K., Mehlhorn, J., May-Taube, K., Welticke, B., Frank, K.H., Baur, X. Int. Arch. Allergy Immunol. (1996) [Pubmed]
  13. An analysis of HLA class II gene polymorphism in British and Greek idiopathic membranous nephropathy patients. Vaughan, R.W., Tighe, M.R., Boki, K., Alexoupolos, S., Papadakis, J., Lanchbury, J.S., Welsh, K.I., Williams, D.G. Eur. J. Immunogenet. (1995) [Pubmed]
  14. HLA-DPB polymorphisms: Glu 69 association with sarcoidosis. Lympany, P.A., Petrek, M., Southcott, A.M., Newman Taylor, A.J., Welsh, K.I., du Bois, R.M. Eur. J. Immunogenet. (1996) [Pubmed]
  15. The HLA class II locus DPB1 can influence susceptibility to type 1 diabetes. Noble, J.A., Valdes, A.M., Thomson, G., Erlich, H.A. Diabetes (2000) [Pubmed]
  16. Association between HLA-DPB1 matching and 1-year rejection-free graft survival in high-risk corneal transplantation. Munkhbat, B., Hagihara, M., Sato, T., Tsuchida, F., Sato, K., Shimazaki, J., Tsubota, K., Tsuji, K. Transplantation (1997) [Pubmed]
  17. New genomic region for Wegener's granulomatosis as revealed by an extended association screen with 202 apoptosis-related genes. Jagiello, P., Gencik, M., Arning, L., Wieczorek, S., Kunstmann, E., Csernok, E., Gross, W.L., Epplen, J.T. Hum. Genet. (2004) [Pubmed]
  18. Linkage disequilibrium between HLA-DPB1 alleles and retinoid X receptor beta haplotypes. Rajsbaum, R., Fici, D., Boggs, D.A., Fraser, P.A., Flores-Villanueva, P.O., Awdeh, Z.L. Hum. Immunol. (2002) [Pubmed]
  19. A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation. Zino, E., Frumento, G., Marktel, S., Sormani, M.P., Ficara, F., Di Terlizzi, S., Parodi, A.M., Sergeant, R., Martinetti, M., Bontadini, A., Bonifazi, F., Lisini, D., Mazzi, B., Rossini, S., Servida, P., Ciceri, F., Bonini, C., Lanino, E., Bandini, G., Locatelli, F., Apperley, J., Bacigalupo, A., Ferrara, G.B., Bordignon, C., Fleischhauer, K. Blood (2004) [Pubmed]
  20. The relationship between human sperm fertilizing capacity and histocompatibility linked antigen (HLA) alleles gene sequences. Chan, P.J., Su, B.C., Kalugdan, T.H., Tredway, D.R. Hum. Reprod. (1994) [Pubmed]
  21. Biochemical analysis of HLA-DP gene products by isoelectric focusing and comparison with cellular and molecular genetic typing results. Rebmann, V., Kubens, B.S., Ferencik, S., Grosse-Wilde, H. Exp. Clin. Immunogenet. (1995) [Pubmed]
  22. Matching for HLA DPA1 and DPB1 alleles in unrelated bone marrow transplantation. Varney, M.D., Lester, S., McCluskey, J., Gao, X., Tait, B.D. Hum. Immunol. (1999) [Pubmed]
  23. HLA class II alleles in isocyanate-induced asthma. Bignon, J.S., Aron, Y., Ju, L.Y., Kopferschmitt, M.C., Garnier, R., Mapp, C., Fabbri, L.M., Pauli, G., Lockhart, A., Charron, D. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  24. Beryllium sensitivity is linked to HLA-DP genotype. Wang, Z., Farris, G.M., Newman, L.S., Shou, Y., Maier, L.A., Smith, H.N., Marrone, B.L. Toxicology (2001) [Pubmed]
  25. HLA-DPB1 alleles in house dust mite allergic patients. O'Brien, R.M., Tait, B.D., Varney, M.D., Thomas, W.R. Eur. J. Immunogenet. (1999) [Pubmed]
  26. Chronic beryllium disease: a hypersensitivity disorder. Rossman, M.D. Applied occupational and environmental hygiene. (2001) [Pubmed]
  27. Three new DPB1 alleles identified in a Bantu-speaking population from central Cameroon. Zimmerman, P.A., Steiner, L.L., Titanji, V.P., Nde, P.N., Bradley, J.E., Pogonka, T., Begovich, A.B. Tissue Antigens (1996) [Pubmed]
  28. Human X-box-binding protein 1 is required for the transcription of a subset of human class II major histocompatibility genes and forms a heterodimer with c-fos. Ono, S.J., Liou, H.C., Davidon, R., Strominger, J.L., Glimcher, L.H. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  29. HLA-DPB1 polymorphism in patients with rheumatoid arthritis in Taiwan. Yen, J.H., Chen, J.R., Tsai, W.J., Tsai, J.J., Liu, H.W. J. Rheumatol. (1995) [Pubmed]
  30. Association of HLA-DPB1*0301 with IDDM in Mexican-Americans. Erlich, H.A., Rotter, J.I., Chang, J.D., Shaw, S.J., Raffel, L.J., Klitz, W., Bugawan, T.L., Zeidler, A. Diabetes (1996) [Pubmed]
  31. Differential evolutionary MHC class II strategies in humans and rhesus macaques: relevance for biomedical studies. Doxiadis, G.G., Otting, N., de Groot, N.G., Bontrop, R.E. Immunol. Rev. (2001) [Pubmed]
  32. Lack of primary association between transporter associated with antigen processing genes and atopic dermatitis. Kuwata, S., Yanagisawa, M., Saeki, H., Nakagawa, H., Etoh, T., Tokunaga, K., Juji, T., Shibata, Y. J. Allergy Clin. Immunol. (1995) [Pubmed]
  33. Erosive rheumatoid factor negative and positive rheumatoid arthritis are immunogenetically similar. Vehe, R.K., Nepom, G.T., Wilske, K.R., Stage, D., Begovich, A.B., Nepom, B.S. J. Rheumatol. (1994) [Pubmed]
  34. Gene polymorphism of HLA-DPB1 and DPA1 loci in caucasoid population: frequencies and DPB1-DPA1 associations. al-Daccak, R., Wang, F.Q., Theophille, D., Lethielleux, P., Colombani, J., Loiseau, P. Hum. Immunol. (1991) [Pubmed]
  35. DPB1 disparities contribute to severe GVHD and reduced patient survival after unrelated donor bone marrow transplantation. Loiseau, P., Espérou, H., Busson, M., Sghiri, R., Tamouza, R., Hilarius, M., Raffoux, C., Devergie, A., Ribaud, P., Socié, G., Gluckman, E., Charron, D. Bone Marrow Transplant. (2002) [Pubmed]
  36. HLA-DPB1*0201 is associated with particular clinical features of rheumatoid arthritis. Carthy, D., MacGregor, A., Awomoi, A., Rigby, A.S., Thomson, W., Donn, R., Silman, A., Ollier, W. Revue du rhumatisme (English ed.) (1995) [Pubmed]
  37. Crucial role of the third and fourth hypervariable regions of HLA-DPB1 allelic sequences in the mixed lymphocyte reaction. Cesbron, A., Moreau, P., Milpied, N., Harousseau, J.L., Muller, J.Y., Bignon, J.D. Hum. Immunol. (1992) [Pubmed]
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