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Gene Review:

ND4 - NADH dehydrogenase subunit 4

Bos grunniens

Fearnley, I.M. et al., Finel, M. et al., Krugner-Higby, L. et al.

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Disease relevance of ND4

The present report describes a severe, necrotizing enterocolitis associated with overgrowth of C. perfringens type A in lactating Swiss-derived (ND4) mice [1].

High impact information on ND4

The sequences of many of them contain hydrophobic segments that could be membrane spanning, including at least two mitochondrial gene products, ND4 and ND5 [2].
The mitochondrial gene product, ND4, a hydrophobic component of complex I with an apparent molecular mass of about 39 kDa, has been identified in preparations of the enzyme [3].

References

Clostridial Enteropathy in Lactating Outbred Swiss-derived (ICR) Mice. Krugner-Higby, L., Girard, I., Welter, J., Gendron, A., Rhodes, J.S., Garland, T. J. Am. Assoc. Lab. Anim. Sci. (2006) [Pubmed]
Resolution of NADH:ubiquinone oxidoreductase from bovine heart mitochondria into two subcomplexes, one of which contains the redox centers of the enzyme. Finel, M., Skehel, J.M., Albracht, S.P., Fearnley, I.M., Walker, J.E. Biochemistry (1992) [Pubmed]
NADH:ubiquinone oxidoreductase from bovine heart mitochondria. cDNA sequences of the import precursors of the nuclear-encoded 39 kDa and 42 kDa subunits. Fearnley, I.M., Finel, M., Skehel, J.M., Walker, J.E. Biochem. J. (1991) [Pubmed]

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