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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genes, Mitochondrial

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Disease relevance of Genes, Mitochondrial


Psychiatry related information on Genes, Mitochondrial


High impact information on Genes, Mitochondrial

  • MTF, a murine minor histocompatibility antigen, is maternally inherited and thought to be encoded by a mitochondrial gene [7].
  • This maturase is required to splice the fourth intron of this gene and to splice the fourth intron of the mitochondrial gene oxi3 encoding cytochrome oxidase subunit I. We have cloned the nuclear gene NAM2, which codes for two overlapping RNAs, 3.2 kb and 3.0 kb long, which are transcribed in the same direction but differ at their 5' ends [8].
  • An mRNA maturase is encoded by the first intron of the mitochondrial gene for the subunit I of cytochrome oxidase in S. cerevisiae [9].
  • The Zea mays mitochondrial gene coding cytochrome oxidase subunit II has an intervening sequence and does not contain TGA codons [10].
  • The mRNAs from two yeast mitochondrial genes cob-box (cytochrome b) and oxi-3 (cytochrome oxidase 40,000 dalton subunit) are processed from large (7-10 kb) precursors [11].

Chemical compound and disease context of Genes, Mitochondrial


Biological context of Genes, Mitochondrial


Anatomical context of Genes, Mitochondrial


Associations of Genes, Mitochondrial with chemical compounds

  • The ability of interferon to reduce mitochondrial mRNA levels could be blocked by cycloheximide suggesting that these effects are mediated by an interferon-responsive nuclear gene which encodes a product capable of regulating mitochondrial gene expression [24].
  • To test the validity of this notion, we have taken advantage of our ability to discriminate, by mobility differences on sodium dodecyl sulfate/polyacrylamide gels, different forms of the product of alleles of the mitochondrial gene, varI [25].
  • Its catalytic centers, however, are encoded exclusively by two mitochondrial genes, CO1 and CO2 (encoding CO subunits I and II, respectively) [26].
  • Since some other kinetoplastid mitochondrial genes also lack conventional initiation codons, creation of initiation codons may be an important function of uridine addition [27].
  • Lack of phenotypic change suggests that mitochondrial gene expression has not been noticeably disrupted in SPR1 despite deletion of the consensus nonomer promoter upstream from the glutamic acid tRNA gene [28].

Gene context of Genes, Mitochondrial


Analytical, diagnostic and therapeutic context of Genes, Mitochondrial


  1. X chromosome-linked and mitochondrial gene control of Leber hereditary optic neuropathy: evidence from segregation analysis for dependence on X chromosome inactivation. Bu, X.D., Rotter, J.I. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  2. Male-sterility induction in transgenic tobacco plants with an unedited atp9 mitochondrial gene from wheat. Hernould, M., Suharsono, S., Litvak, S., Araya, A., Mouras, A. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  3. Leber's hereditary optic neuropathy mitochondrial DNA mutations in multiple sclerosis. Kellar-Wood, H., Robertson, N., Govan, G.G., Compston, D.A., Harding, A.E. Ann. Neurol. (1994) [Pubmed]
  4. Effects of fatty acids on expression of genes encoding subunits of cytochrome c oxidase and cytochrome c oxidase activity in HT29 human colonic adenocarcinoma cells. Heerdt, B.G., Augenlicht, L.H. J. Biol. Chem. (1991) [Pubmed]
  5. Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. Lee, J., Kim, C.H., Simon, D.K., Aminova, L.R., Andreyev, A.Y., Kushnareva, Y.E., Murphy, A.N., Lonze, B.E., Kim, K.S., Ginty, D.D., Ferrante, R.J., Ryu, H., Ratan, R.R. J. Biol. Chem. (2005) [Pubmed]
  6. Time-course of mitochondrial gene expressions in mice brains: implications for mitochondrial dysfunction, oxidative damage, and cytochrome c in aging. Manczak, M., Jung, Y., Park, B.S., Partovi, D., Reddy, P.H. J. Neurochem. (2005) [Pubmed]
  7. Maternally transmitted histocompatibility antigen of mice: a hydrophobic peptide of a mitochondrially encoded protein. Loveland, B., Wang, C.R., Yonekawa, H., Hermel, E., Lindahl, K.F. Cell (1990) [Pubmed]
  8. The yeast nuclear gene NAM2 is essential for mitochondrial DNA integrity and can cure a mitochondrial RNA-maturase deficiency. Labouesse, M., Dujardin, G., Slonimski, P.P. Cell (1985) [Pubmed]
  9. An mRNA maturase is encoded by the first intron of the mitochondrial gene for the subunit I of cytochrome oxidase in S. cerevisiae. Carignani, G., Groudinsky, O., Frezza, D., Schiavon, E., Bergantino, E., Slonimski, P.P. Cell (1983) [Pubmed]
  10. The Zea mays mitochondrial gene coding cytochrome oxidase subunit II has an intervening sequence and does not contain TGA codons. Fox, T.D., Leaver, C.J. Cell (1981) [Pubmed]
  11. Pleiotropic mutations within two yeast mitochondrial cytochrome genes block mRNA processing. Church, G.M., Slonimski, P.P., Gilbert, W. Cell (1979) [Pubmed]
  12. Aging and high concentrations of glucose potentiate injury to mitochondrial DNA. Fukagawa, N.K., Li, M., Liang, P., Russell, J.C., Sobel, B.E., Absher, P.M. Free Radic. Biol. Med. (1999) [Pubmed]
  13. Coordination of nuclear and mitochondrial gene expression during the development of cardiac hypertrophy in rats. Wiesner, R.J., Aschenbrenner, V., Rüegg, J.C., Zak, R. Am. J. Physiol. (1994) [Pubmed]
  14. Escape of DNA from mitochondria to the nucleus in Saccharomyces cerevisiae. Thorsness, P.E., Fox, T.D. Nature (1990) [Pubmed]
  15. Multiple trans-splicing events are required to produce a mature nad1 transcript in a plant mitochondrion. Conklin, P.L., Wilson, R.K., Hanson, M.R. Genes Dev. (1991) [Pubmed]
  16. Diabetes mellitus associated with a pathogenic point mutation in mitochondrial DNA. Reardon, W., Ross, R.J., Sweeney, M.G., Luxon, L.M., Pembrey, M.E., Harding, A.E., Trembath, R.C. Lancet (1992) [Pubmed]
  17. The mitochondrial genome of the fission yeast Schizosaccharomyces pombe: highly homologous introns are inserted at the same position of the otherwise less conserved cox1 genes in Schizosaccharomyces pombe and Aspergillus nidulans. Lang, B.F. EMBO J. (1984) [Pubmed]
  18. Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis. Virbasius, J.V., Scarpulla, R.C. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  19. Mitochondrial inheritance is delayed in Saccharomyces cerevisiae cells lacking the serine/threonine phosphatase PTC1. Roeder, A.D., Hermann, G.J., Keegan, B.R., Thatcher, S.A., Shaw, J.M. Mol. Biol. Cell (1998) [Pubmed]
  20. Regulation by thyroid hormone of nuclear and mitochondrial genes encoding subunits of cytochrome-c oxidase in rat liver and skeletal muscle. Wiesner, R.J., Kurowski, T.T., Zak, R. Mol. Endocrinol. (1992) [Pubmed]
  21. Effects of ethidium bromide treatment of mouse cells on expression and assembly of nuclear-coded subunits of complexes involved in the oxidative phosphorylation. Hayashi, J., Tanaka, M., Sato, W., Ozawa, T., Yonekawa, H., Kagawa, Y., Ohta, S. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  22. Genes for the ribosomal S4 protein encoded in higher plant mitochondria are transcribed, edited, and translated. Handa, H., Kubo, N., Kadowaki, K. Mol. Gen. Genet. (1998) [Pubmed]
  23. Enhanced mitochondrial gene transcript, ATP, bcl-2 protein levels, and altered glutathione distribution in ethinyl estradiol-treated cultured female rat hepatocytes. Chen, J., Delannoy, M., Odwin, S., He, P., Trush, M.A., Yager, J.D. Toxicol. Sci. (2003) [Pubmed]
  24. Interferon selectively inhibits the expression of mitochondrial genes: a novel pathway for interferon-mediated responses. Shan, B., Vazquez, E., Lewis, J.A. EMBO J. (1990) [Pubmed]
  25. Expression of petite mitochondrial DNA in vivo: zygotic gene rescue. Strausberg, R.L., Butow, R.A. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  26. Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease. Davis, R.E., Miller, S., Herrnstadt, C., Ghosh, S.S., Fahy, E., Shinobu, L.A., Galasko, D., Thal, L.J., Beal, M.F., Howell, N., Parker, W.D. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  27. Creation of AUG initiation codons by addition of uridines within cytochrome b transcripts of kinetoplastids. Feagin, J.E., Shaw, J.M., Simpson, L., Stuart, K. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  28. In vivo rearrangement of mitochondrial DNA in Saccharomyces cerevisiae. Clark-Walker, G.D. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  29. The ATP-dependent PIM1 protease is required for the expression of intron-containing genes in mitochondria. van Dyck, L., Neupert, W., Langer, T. Genes Dev. (1998) [Pubmed]
  30. c-MYC apoptotic function is mediated by NRF-1 target genes. Morrish, F., Giedt, C., Hockenbery, D. Genes Dev. (2003) [Pubmed]
  31. The formation of respiratory chain complexes in mitochondria is under the proteolytic control of the m-AAA protease. Arlt, H., Steglich, G., Perryman, R., Guiard, B., Neupert, W., Langer, T. EMBO J. (1998) [Pubmed]
  32. At least two nuclear gene products are specifically required for translation of a single yeast mitochondrial mRNA. Costanzo, M.C., Seaver, E.C., Fox, T.D. EMBO J. (1986) [Pubmed]
  33. The yeast gene, MDM20, is necessary for mitochondrial inheritance and organization of the actin cytoskeleton. Hermann, G.J., King, E.J., Shaw, J.M. J. Cell Biol. (1997) [Pubmed]
  34. Two overlapping genes in bovine mitochondrial DNA encode membrane components of ATP synthase. Fearnley, I.M., Walker, J.E. EMBO J. (1986) [Pubmed]
  35. A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae. Fisk, H.A., Yaffe, M.P. J. Cell Biol. (1999) [Pubmed]
  36. Regional absence of mitochondria causing energy depletion in the myocardium of muscle LIM protein knockout mice. van den Bosch, B.J., van den Burg, C.M., Schoonderwoerd, K., Lindsey, P.J., Scholte, H.R., de Coo, R.F., van Rooij, E., Rockman, H.A., Doevendans, P.A., Smeets, H.J. Cardiovasc. Res. (2005) [Pubmed]
  37. DNA differential diagnosis of human taeniid cestodes by base excision sequence scanning thymine-base reader analysis with mitochondrial genes. Yamasaki, H., Nakao, M., Sako, Y., Nakaya, K., Sato, M.O., Mamuti, W., Okamoto, M., Ito, A. J. Clin. Microbiol. (2002) [Pubmed]
  38. Overexpression of mitochondrial genes in alloplasmic common wheat with a cytoplasm of wheatgrass (Agropyron trichophorum) showing depressed vigor and male sterility. Suzuki, T., Nakamura, C., Mori, N., Kaneda, C. Plant Mol. Biol. (1995) [Pubmed]
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