Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

N - nucleoprotein N

Mokola virus

Mebatsion, T. et al., Fu, Z.F. et al.

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Disease relevance of N

A cDNA copy of the RNA gene that encodes the nucleoprotein N of rabies virus Evelyn-Rokitnicki-Abelseth strain was cloned into baculovirus [1].

High impact information on N

As determined by cosedimentation experiments, not only the M-RNP complex but also M alone was found to interact specifically with the glycoprotein G. In contrast, an interaction of G with the nucleoprotein N or M-less RNP was not observed [2].

References

Rabies virus nucleoprotein expressed in and purified from insect cells is efficacious as a vaccine. Fu, Z.F., Dietzschold, B., Schumacher, C.L., Wunner, W.H., Ertl, H.C., Koprowski, H. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
Matrix protein of rabies virus is responsible for the assembly and budding of bullet-shaped particles and interacts with the transmembrane spike glycoprotein G. Mebatsion, T., Weiland, F., Conzelmann, K.K. J. Virol. (1999) [Pubmed]

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