Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

FOXA3 - forkhead box A3

Homo sapiens

Synonyms: FKHH3, Fork head-related protein FKH H3, Forkhead box protein A3, HNF-3-gamma, HNF-3G, ...

Rodríguez-Antona, C. et al., Friedman, J.R. et al., Wolfrum, C. et al.

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High impact information on FOXA3

Foxa-2 physically interacts with Akt, a key mediator of the phosphatidylinositol 3-kinase pathway and is phosphorylated at a single conserved site (T156) that is absent in Foxa-1 and Foxa-3 proteins [1].
Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma [2].

Biological context of FOXA3

During this time its three members, Foxa1, Foxa2 and Foxa3, have been found to play important roles in multiple stages of mammalian life, beginning with early development, continuing during organogenesis, and finally in metabolism and homeostasis in the adult [3].

References

Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization. Wolfrum, C., Besser, D., Luca, E., Stoffel, M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma. Rodríguez-Antona, C., Bort, R., Jover, R., Tindberg, N., Ingelman-Sundberg, M., Gómez-Lechón, M.J., Castell, J.V. Mol. Pharmacol. (2003) [Pubmed]
The Foxa family of transcription factors in development and metabolism. Friedman, J.R., Kaestner, K.H. Cell. Mol. Life Sci. (2006) [Pubmed]

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