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Gene Review

Foxa3  -  forkhead box A3

Mus musculus

Synonyms: Forkhead box protein A3, HNF-3-gamma, HNF-3G, Hepatocyte nuclear factor 3-gamma, Hnf-3g, ...
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Disease relevance of Foxa3


High impact information on Foxa3


Biological context of Foxa3


Anatomical context of Foxa3


Associations of Foxa3 with chemical compounds

  • However, when fasted, Foxa3(-/-) mice have a significantly lower blood glucose compared with control mice [1].

Regulatory relationships of Foxa3

  • In addition, we investigated the hepatic transcription factor network in Foxa3(-/-) mice and found that the normal activation of HNF-4alpha, HNF-1alpha, and PGC-1 induced by fasting is attenuated in mice lacking Foxa3 [1].

Other interactions of Foxa3


  1. Foxa3 (hepatocyte nuclear factor 3gamma ) is required for the regulation of hepatic GLUT2 expression and the maintenance of glucose homeostasis during a prolonged fast. Shen, W., Scearce, L.M., Brestelli, J.E., Sund, N.J., Kaestner, K.H. J. Biol. Chem. (2001) [Pubmed]
  2. Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Silberg, D.G., Sullivan, J., Kang, E., Swain, G.P., Moffett, J., Sund, N.J., Sackett, S.D., Kaestner, K.H. Gastroenterology (2002) [Pubmed]
  3. Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach. Katz, J.P., Perreault, N., Goldstein, B.G., Actman, L., McNally, S.R., Silberg, D.G., Furth, E.E., Kaestner, K.H. Gastroenterology (2005) [Pubmed]
  4. Transcriptional regulation in endoderm development: characterization of an enhancer controlling Hnf3g expression by transgenesis and targeted mutagenesis. Hiemisch, H., Schütz, G., Kaestner, K.H. EMBO J. (1997) [Pubmed]
  5. Foxa3 (HNF-3gamma) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression. Liu, Y., Shen, W., Brubaker, P.L., Kaestner, K.H., Drucker, D.J. Biochem. J. (2002) [Pubmed]
  6. Targeted disruption of the gene encoding hepatocyte nuclear factor 3gamma results in reduced transcription of hepatocyte-specific genes. Kaestner, K.H., Hiemisch, H., Schütz, G. Mol. Cell. Biol. (1998) [Pubmed]
  7. Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage. Hughes, D.E., Stolz, D.B., Yu, S., Tan, Y., Reddy, J.K., Watkins, S.C., Diehl, A.M., Costa, R.H. Hepatology (2003) [Pubmed]
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