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Gene Review

Gbeta5  -  CG10763 gene product from transcript...

Drosophila melanogaster

Synonyms: CG10763, Dmel\CG10763, G[[beta5]], G[[beta]], Gbeta, ...
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Disease relevance of Gbeta5

  • The more prolonged receptor-mediated changes in adenylyl cyclase activity are generated by an independent G-protein-coupled pathway that is pertussis toxin-sensitive but calcium-independent, and Gbetagamma-subunits appear to be involved in the transduction of this response [1].

High impact information on Gbeta5

  • As is the case with mammalian GRK2 and GRK3, Drosophila GPRK1 includes a C-terminal pleckstrin homology domain, which binds to phosphoinositides and the Gbetagamma subunit [2].
  • Light-activated Galpha(q)- guanosine 5'-O-(thiotriphosphate) and AlF(4)(-)-activated Galpha(q), but not Gbetagamma, form a stable complex with the INAD signaling complex [3].


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