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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Gbeta5  -  CG10763 gene product from transcript...

Drosophila melanogaster

Synonyms: CG10763, Dmel\CG10763, G[[beta5]], G[[beta]], Gbeta, ...
 
 
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Disease relevance of Gbeta5

  • The more prolonged receptor-mediated changes in adenylyl cyclase activity are generated by an independent G-protein-coupled pathway that is pertussis toxin-sensitive but calcium-independent, and Gbetagamma-subunits appear to be involved in the transduction of this response [1].
 

High impact information on Gbeta5

  • As is the case with mammalian GRK2 and GRK3, Drosophila GPRK1 includes a C-terminal pleckstrin homology domain, which binds to phosphoinositides and the Gbetagamma subunit [2].
  • Light-activated Galpha(q)- guanosine 5'-O-(thiotriphosphate) and AlF(4)(-)-activated Galpha(q), but not Gbetagamma, form a stable complex with the INAD signaling complex [3].

References

  1. Agonist-specific coupling of a cloned Drosophila melanogaster D1-like dopamine receptor to multiple second messenger pathways by synthetic agonists. Reale, V., Hannan, F., Hall, L.M., Evans, P.D. J. Neurosci. (1997) [Pubmed]
  2. Rhodopsin kinase activity modulates the amplitude of the visual response in Drosophila. Lee, S.J., Xu, H., Montell, C. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. The visual G protein of fly photoreceptors interacts with the PDZ domain assembled INAD signaling complex via direct binding of activated Galpha(q) to phospholipase cbeta. Bähner, M., Sander, P., Paulsen, R., Huber, A. J. Biol. Chem. (2000) [Pubmed]
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