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Gene Review:

US12 - inhibits antigen presentation

Cercopithecine herpesvirus 2

Ahn, K. et al., Galocha, B. et al.

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Disease relevance of US12

The herpes simplex virus (HSV) immediate early protein ICP47 inhibits the transporter associated with antigen processing (TAP)-dependent peptide translocation [1].

High impact information on US12

The immediate early protein ICP47 of herpes simplex virus (HSV) inhibits the transporter for antigen processing (TAP)-mediated translocation of antigen-derived peptides across the endoplasmic reticulum (ER) membrane [2].

References

The active site of ICP47, a herpes simplex virus-encoded inhibitor of the major histocompatibility complex (MHC)-encoded peptide transporter associated with antigen processing (TAP), maps to the NH2-terminal 35 residues. Galocha, B., Hill, A., Barnett, B.C., Dolan, A., Raimondi, A., Cook, R.F., Brunner, J., McGeoch, D.J., Ploegh, H.L. J. Exp. Med. (1997) [Pubmed]
Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47. Ahn, K., Meyer, T.H., Uebel, S., Sempé, P., Djaballah, H., Yang, Y., Peterson, P.A., Früh, K., Tampé, R. EMBO J. (1996) [Pubmed]

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