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Gene Review

US12  -  inhibits antigen presentation

Cercopithecine herpesvirus 2

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Disease relevance of US12


High impact information on US12


  1. The active site of ICP47, a herpes simplex virus-encoded inhibitor of the major histocompatibility complex (MHC)-encoded peptide transporter associated with antigen processing (TAP), maps to the NH2-terminal 35 residues. Galocha, B., Hill, A., Barnett, B.C., Dolan, A., Raimondi, A., Cook, R.F., Brunner, J., McGeoch, D.J., Ploegh, H.L. J. Exp. Med. (1997) [Pubmed]
  2. Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47. Ahn, K., Meyer, T.H., Uebel, S., Sempé, P., Djaballah, H., Yang, Y., Peterson, P.A., Früh, K., Tampé, R. EMBO J. (1996) [Pubmed]
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