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Gene Review:

Cxxc4 - CXXC finger 4

Mus musculus

Synonyms: 9330210J02Rik, C030003J12Rik, CXXC-type zinc finger protein 4, Idax, Inhibition of the Dvl and axin complex protein

London, T.B. et al., Hino, S. et al.

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High impact information on Cxxc4

Therefore, these results suggest that Idax functions as a negative regulator of the Wnt signaling pathway by directly binding to the PDZ domain of Dvl [1].
Further, Wnt-induced accumulation of beta-catenin and activation of T-cell factor in mammalian cells were suppressed by expression of Idax [1].

Physical interactions of Cxxc4

We first confirmed that the C-terminal region of Idax consisting of residues 109-198 binds to the PDZ domain of mouse Dvl-1 at the conventional C-terminal peptide-binding groove [2].

Other interactions of Cxxc4

In an effort to clarify the structural basis of this interaction, we used nuclear magnetic resonance spectroscopy to study the interaction of the Dvl PDZ domain with Idax [2].

References

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Hino, S., Kishida, S., Michiue, T., Fukui, A., Sakamoto, I., Takada, S., Asashima, M., Kikuchi, A. Mol. Cell. Biol. (2001) [Pubmed]
Interaction between the internal motif KTXXXI of Idax and mDvl PDZ domain. London, T.B., Lee, H.J., Shao, Y., Zheng, J. Biochem. Biophys. Res. Commun. (2004) [Pubmed]

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