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Gene Review

Ctnnb1  -  catenin (cadherin associated protein), beta 1

Rattus norvegicus

Synonyms: Beta-catenin, Catenin beta-1, Catnb
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Disease relevance of Ctnnb1


High impact information on Ctnnb1

  • Mechanistically, we show that quiescent blood vessels contain a complex involving Flk, VE-cadherin, and beta-catenin that is transiently disrupted by VEGF injection [5].
  • Here, we demonstrate that beta-catenin, which mediates interactions between cadherins and the actin cytoskeleton, moves from dendritic shafts into spines upon depolarization, increasing its association with cadherins. beta-catenin's redistribution was mimicked or prevented by a tyrosine kinase or phosphatase inhibitor, respectively [6].
  • In Y654F-expressing neurons, the PSD-95 or associated synapsin-I clusters were larger than those observed in either wild-type-beta-catenin or also Y654E-expressing neurons [6].
  • E-cadherin/beta-catenin complexes disintegrated and reassembled completely in parallel on immunoprecipitation experiments [4].
  • Thus, beta-catenin binding to the whole cytoplasmic domain of E-cadherin correlates with efficient and targeted delivery of E-cadherin to the lateral plasma membrane [7].

Chemical compound and disease context of Ctnnb1


Biological context of Ctnnb1


Anatomical context of Ctnnb1


Associations of Ctnnb1 with chemical compounds

  • To determine the possible involvement of such mutations during chemically induced colon carcinogenesis, we examined the corresponding region of Ctnnb1 in colon tumors induced in the F344 rat by two cooked meat heterocyclic amines, 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) [1].
  • Such frequent mutations of the beta-catenin gene in azoxymethane-induced rat colon tumors suggest that consequent alterations in the stability and localization of the protein may play an important role in this colon carcinogenesis model [14].
  • We show this increase to be the result of decreased degradation of beta-catenin (decrease in serine phosphorylated beta-catenin) as seen by immunoprecipitation studies [13].
  • Glycogen Synthase Kinase-3 Inactivation and Stabilization of beta-Catenin Induce Nephron Differentiation in Isolated Mouse and Rat Kidney Mesenchymes [18].
  • Retention of membrane-localized beta-catenin in cells lacking functional polycystin-1 and tuberin [15].
  • These findings suggest an indirect pathway for Bcl-2 over-expression in PhIP-induced colon tumors involving beta-catenin, c-Myc and E2F1 [19].

Physical interactions of Ctnnb1


Regulatory relationships of Ctnnb1


Other interactions of Ctnnb1


Analytical, diagnostic and therapeutic context of Ctnnb1


  1. High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat. Dashwood, R.H., Suzui, M., Nakagama, H., Sugimura, T., Nagao, M. Cancer Res. (1998) [Pubmed]
  2. Beta-catenin, an inducer of uncontrolled cell proliferation and migration in malignancies, is localized in the cytoplasm of vascular endothelium during neovascularization after myocardial infarction. Blankesteijn, W.M., van Gijn, M.E., Essers-Janssen, Y.P., Daemen, M.J., Smits, J.F. Am. J. Pathol. (2000) [Pubmed]
  3. Different mutation status of the beta-catenin gene in carcinogen-induced colon, brain, and oral tumors in rats. Suzui, M., Sugie, S., Mori, H., Okuno, M., Tanaka, T., Moriwaki, H. Mol. Carcinog. (2001) [Pubmed]
  4. Dissociation and reassembly of adherens junctions during experimental acute pancreatitis. Lerch, M.M., Lutz, M.P., Weidenbach, H., Müller-Pillasch, F., Gress, T.M., Leser, J., Adler, G. Gastroenterology (1997) [Pubmed]
  5. Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction. Weis, S., Shintani, S., Weber, A., Kirchmair, R., Wood, M., Cravens, A., McSharry, H., Iwakura, A., Yoon, Y.S., Himes, N., Burstein, D., Doukas, J., Soll, R., Losordo, D., Cheresh, D. J. Clin. Invest. (2004) [Pubmed]
  6. Depolarization drives beta-Catenin into neuronal spines promoting changes in synaptic structure and function. Murase, S., Mosser, E., Schuman, E.M. Neuron (2002) [Pubmed]
  7. Coupling assembly of the E-cadherin/beta-catenin complex to efficient endoplasmic reticulum exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cells. Chen, Y.T., Stewart, D.B., Nelson, W.J. J. Cell Biol. (1999) [Pubmed]
  8. Proteomic analysis of intestinal epithelial cells expressing stabilized beta-catenin. Seike, M., Kondo, T., Mori, Y., Gemma, A., Kudoh, S., Sakamoto, M., Yamada, T., Hirohashi, S. Cancer Res. (2003) [Pubmed]
  9. Frequent mutations of the rat beta-catenin gene in colon cancers induced by methylazoxymethanol acetate plus 1-hydroxyanthraquinone. Suzui, M., Ushijima, T., Dashwood, R.H., Yoshimi, N., Sugimura, T., Mori, H., Nagao, M. Mol. Carcinog. (1999) [Pubmed]
  10. Different frequencies and patterns of beta-catenin mutations in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient L-amino acid-defined diet in rats. Tsujiuchi, T., Tsutsumi, M., Sasaki, Y., Takahama, M., Konishi, Y. Cancer Res. (1999) [Pubmed]
  11. Suppression of occurrence and advancement of beta-catenin-accumulated crypts, possible premalignant lesions of colon cancer, by selective cyclooxygenase-2 inhibitor, celecoxib. Yamada, Y., Yoshimi, N., Hirose, Y., Hara, A., Shimizu, M., Kuno, T., Katayama, M., Qiao, Z., Mori, H. Jpn. J. Cancer Res. (2001) [Pubmed]
  12. Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline. Li, Q., Dixon, B.M., Al-Fageeh, M., Blum, C.A., Dashwood, R.H. Gene (2002) [Pubmed]
  13. Changes in WNT/beta-catenin pathway during regulated growth in rat liver regeneration. Monga, S.P., Pediaditakis, P., Mule, K., Stolz, D.B., Michalopoulos, G.K. Hepatology (2001) [Pubmed]
  14. Beta-catenin is frequently mutated and demonstrates altered cellular location in azoxymethane-induced rat colon tumors. Takahashi, M., Fukuda, K., Sugimura, T., Wakabayashi, K. Cancer Res. (1998) [Pubmed]
  15. Retention of membrane-localized beta-catenin in cells lacking functional polycystin-1 and tuberin. Kugoh, H., Kleymenova, E., Walker, C.L. Mol. Carcinog. (2002) [Pubmed]
  16. Comparative expression patterns of T-, N-, E-cadherins, beta-catenin, and polysialic acid neural cell adhesion molecule in rat cochlea during development: implications for the nature of Kölliker's organ. Simonneau, L., Gallego, M., Pujol, R. J. Comp. Neurol. (2003) [Pubmed]
  17. Regulation of dishevelled and beta-catenin in rat skeletal muscle: an alternative exercise-induced GSK-3beta signaling pathway. Aschenbach, W.G., Ho, R.C., Sakamoto, K., Fujii, N., Li, Y., Kim, Y.B., Hirshman, M.F., Goodyear, L.J. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
  18. Glycogen Synthase Kinase-3 Inactivation and Stabilization of beta-Catenin Induce Nephron Differentiation in Isolated Mouse and Rat Kidney Mesenchymes. Kuure, S., Popsueva, A., Jakobson, M., Sainio, K., Sariola, H. J. Am. Soc. Nephrol. (2007) [Pubmed]
  19. Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving beta-catenin, c-Myc and E2F1. Li, Q., Dashwood, W.M., Zhong, X., Nakagama, H., Dashwood, R.H. Oncogene (2007) [Pubmed]
  20. Lithium induces gene expression through lymphoid enhancer-binding factor/T-cell factor responsive element in rat PC12 cells. Bettini, E., Magnani, E., Terstappen, G.C. Neurosci. Lett. (2002) [Pubmed]
  21. Synaptic scaffolding molecule is involved in the synaptic clustering of neuroligin. Iida, J., Hirabayashi, S., Sato, Y., Hata, Y. Mol. Cell. Neurosci. (2004) [Pubmed]
  22. Thyroid hormone interacts with the Wnt/beta-catenin signaling pathway in the terminal differentiation of growth plate chondrocytes. Wang, L., Shao, Y.Y., Ballock, R.T. J. Bone Miner. Res. (2007) [Pubmed]
  23. Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos. Yamamoto, H., Kishida, S., Uochi, T., Ikeda, S., Koyama, S., Asashima, M., Kikuchi, A. Mol. Cell. Biol. (1998) [Pubmed]
  24. Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes. Monga, S.P., Mars, W.M., Pediaditakis, P., Bell, A., Mulé, K., Bowen, W.C., Wang, X., Zarnegar, R., Michalopoulos, G.K. Cancer Res. (2002) [Pubmed]
  25. A mechanism of impaired mobility of oligodendrocyte progenitor cells by tenascin C through modification of wnt signaling. Kakinuma, Y., Saito, F., Osawa, S., Miura, M. FEBS Lett. (2004) [Pubmed]
  26. Expression and function of the developmental gene Wnt-4 during experimental acute renal failure in rats. Terada, Y., Tanaka, H., Okado, T., Shimamura, H., Inoshita, S., Kuwahara, M., Sasaki, S. J. Am. Soc. Nephrol. (2003) [Pubmed]
  27. Modulation of gap and adherens junctional proteins in cultured neonatal pancreatic islets. Collares-Buzato, C.B., Leite, A.R., Boschero, A.C. Pancreas (2001) [Pubmed]
  28. Cyclosporin-induced downregulation of the expression of E-cadherin during proliferation of edentulous gingival epithelium in rats. Tu, H.P., Chen, Y.T., Shieh, Y.S., Chin, Y.T., Huang, R.Y., Yang, S.F., Gau, C.H., Fu, E. J. Periodontol. (2006) [Pubmed]
  29. Rat oligodendrocyte O-2A precursor cells and the CG-4 oligodendrocyte precursor cell line express cadherins, beta-catenin and the neural cell adhesion molecule, NCAM. Hughson, E., Dowler, S., Geall, K., Johnson, G., Rumsby, M. Neurosci. Lett. (1998) [Pubmed]
  30. Glucocorticoids control beta-catenin protein expression and localization through distinct pathways that can be uncoupled by disruption of signaling events required for tight junction formation in rat mammary epithelial tumor cells. Guan, Y., Rubenstein, N.M., Failor, K.L., Woo, P.L., Firestone, G.L. Mol. Endocrinol. (2004) [Pubmed]
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