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Gene Review:

rpoD2 - group2 RNA polymerase sigma factor RpoD2

Synechococcus elongatus PCC 6301

Tsinoremas, N.F. et al., Nair, U. et al.

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Disease relevance of rpoD2

We characterized the disrupted locus of the low amplitude but still rhythmic mutant (M16) as the rpoD2 gene, a member of a gene family that encodes sigma70-like transcription factors in Synechococcus [1].

High impact information on rpoD2

Therefore, we conclude that rpoD2 is a component of an output pathway of the biological clock that affects the circadian expression of a subset of genes in Synechococcus [1].
Overexpression of rpoD2, rpoD3, rpoD4, or sigC also changed the period or abolished the rhythmicity of PpsbAI expression, consistent with a model in which sigma factors work as a consortium to convey circadian information to downstream genes [2].

References

A sigma factor that modifies the circadian expression of a subset of genes in cyanobacteria. Tsinoremas, N.F., Ishiura, M., Kondo, T., Andersson, C.R., Tanaka, K., Takahashi, H., Johnson, C.H., Golden, S.S. EMBO J. (1996) [Pubmed]
Roles for sigma factors in global circadian regulation of the cyanobacterial genome. Nair, U., Ditty, J.L., Min, H., Golden, S.S. J. Bacteriol. (2002) [Pubmed]

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