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Gene Review:

HOXB8 - homeobox B8

Homo sapiens

Synonyms: HOX2, HOX2D, Homeobox protein Hox-2.4, Homeobox protein Hox-2D, Homeobox protein Hox-B8, ...

Kawasaki, H. et al., Shen, W.F. et al.

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High impact information on HOXB8

All eight proteins (Hoxb-1-Hoxb-8) bind to a target oligonucleotide in the presence of Pbx1a under conditions where minimal or no binding is detected for the Hox or Pbx1a proteins alone [1].
MicroRNA-196 inhibits HOXB8 expression in myeloid differentiation of HL60 cells [2].

Anatomical context of HOXB8

These results suggest that miR-196 participates in myeloid differentiation of HL60 cells via regulation of HOXB8 expression [2].

References

Hox homeodomain proteins exhibit selective complex stabilities with Pbx and DNA. Shen, W.F., Chang, C.P., Rozenfeld, S., Sauvageau, G., Humphries, R.K., Lu, M., Lawrence, H.J., Cleary, M.L., Largman, C. Nucleic Acids Res. (1996) [Pubmed]
MicroRNA-196 inhibits HOXB8 expression in myeloid differentiation of HL60 cells. Kawasaki, H., Taira, K. Nucleic acids symposium series (2004) (2004) [Pubmed]

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hoxb8	Xenopus (Silurana) tropicalis

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