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Gene Review:

maf-1 - motility accessory factor

Campylobacter jejuni RM1221

Canals, R. et al., Karlyshev, A.V. et al.

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Disease relevance of maf-1

An Aeromonas hydrophila AH-3 miniTn5 mutant unable to produce polar and lateral flagella was isolated, in which the transposon was inserted into a gene whose encoded protein was an orthologue of the Campylobacter jejuni motility accessory factor (Maf) protein [1].

High impact information on maf-1

Phase variation of the maf1 gene via slipped-strand mispairing partially restored motility of the maf5 mutant [2].
Remarkably, two of these genes (maf1 and maf4) were found to be identical and both contain homopolymeric G tracts [2].

References

Non-structural flagella genes affecting both polar and lateral flagella-mediated motility in Aeromonas hydrophila. Canals, R., Vilches, S., Wilhelms, M., Shaw, J.G., Merino, S., Tomás, J.M. Microbiology (Reading, Engl.) (2007) [Pubmed]
A novel paralogous gene family involved in phase-variable flagella-mediated motility in Campylobacter jejuni. Karlyshev, A.V., Linton, D., Gregson, N.A., Wren, B.W. Microbiology (Reading, Engl.) (2002) [Pubmed]

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