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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

icaC  -  intercellular adhesion protein C

Staphylococcus epidermidis RP62A

 
 
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High impact information on icaC

  • Only when icaA and icaD were expressed together with icaC were oligomer chains that react with PIA-specific antiserum synthesized [1].
  • The data obtained in these analyses suggested that in approximately 30% of the variants the missing biofilm formation was due to the inactivation of either the icaA or the icaC gene by the insertion of the insertion sequence element IS256 [2].
  • After repeated passages the insertion mutant was able to revert to a biofilm-forming phenotype which was due to the precise excision of IS256 from the icaC gene [3].
 

Biological context of icaC

  • Inactivation of icaA, icaB, or icaC in pCN27 led to the complete loss of the intercellular adhesion phenotype in S. carnosus, suggesting that all three genes are involved in intercellular adhesion, PIA expression, and translocation [4].
 

Associations of icaC with chemical compounds

  • The detection of the genes governing the production of such extracellular polysaccharide and, in particular, the icaA, the icaC and the icaD genes, provides us with a rapid and accurate technique for strain characterization [5].

References

  1. Characterization of the N-acetylglucosaminyltransferase activity involved in the biosynthesis of the Staphylococcus epidermidis polysaccharide intercellular adhesin. Gerke, C., Kraft, A., Süssmuth, R., Schweitzer, O., Götz, F. J. Biol. Chem. (1998) [Pubmed]
  2. A novel mechanism of phase variation of virulence in Staphylococcus epidermidis: evidence for control of the polysaccharide intercellular adhesin synthesis by alternating insertion and excision of the insertion sequence element IS256. Ziebuhr, W., Krimmer, V., Rachid, S., Lössner, I., Götz, F., Hacker, J. Mol. Microbiol. (1999) [Pubmed]
  3. Detection of the icaADBC gene cluster and biofilm formation in Staphylococcus epidermidis isolates from catheter-related urinary tract infections. Cho, S.H., Naber, K., Hacker, J., Ziebuhr, W. Int. J. Antimicrob. Agents (2002) [Pubmed]
  4. Molecular basis of intercellular adhesion in the biofilm-forming Staphylococcus epidermidis. Heilmann, C., Schweitzer, O., Gerke, C., Vanittanakom, N., Mack, D., Götz, F. Mol. Microbiol. (1996) [Pubmed]
  5. Detection of biofilm-forming strains of Staphylococcus epidermidis and S. aureus. Arciola, C.R., Campoccia, D., Montanaro, L. Expert Rev. Mol. Diagn. (2002) [Pubmed]
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