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Gene Review:

U12 - type 3 membrane protein; 7 transmembrane...

Human herpesvirus 7

Latchney, L.R. et al., Isegawa, Y. et al., Tadagaki, K. et al., Nakano, K. et al.

Isegawa, Ping, Nakano, Sugimoto, Yamanishi,

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Disease relevance of U12

Human herpesvirus 7 open reading frame U12 encodes a functional beta-chemokine receptor [1].
These findings suggested that the product of U12 may play an important role in the pathogenesis of HHV- 6 through transmembrane signaling by binding with beta-chemokines [2].

High impact information on U12

Human herpesvirus 7 open reading frames U12 and U51 encode functional beta-chemokine receptors [3].
Moreover, salivary glands are a major site for the persistent and productive infection by human herpesvirus (HHV)-7, which encodes two putative fractalkine-binding gene products, U12 and U51 [4].

References

Human herpesvirus 7 open reading frame U12 encodes a functional beta-chemokine receptor. Nakano, K., Tadagaki, K., Isegawa, Y., Aye, M.M., Zou, P., Yamanishi, K. J. Virol. (2003) [Pubmed]
Human herpesvirus 6 open reading frame U12 encodes a functional beta-chemokine receptor. Isegawa, Y., Ping, Z., Nakano, K., Sugimoto, N., Yamanishi, K. J. Virol. (1998) [Pubmed]
Human herpesvirus 7 open reading frames U12 and U51 encode functional beta-chemokine receptors. Tadagaki, K., Nakano, K., Yamanishi, K. J. Virol. (2005) [Pubmed]
Immunohistochemical assessment of fractalkine, inflammatory cells, and human herpesvirus 7 in human salivary glands. Latchney, L.R., Fallon, M.A., Culp, D.J., Gelbard, H.A., Dewhurst, S. J. Histochem. Cytochem. (2004) [Pubmed]

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