The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Herpesvirus 6, Human

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Herpesvirus 6, Human


Psychiatry related information on Herpesvirus 6, Human

  • Our results demonstrate that undifferentiated HM were highly resistant to HHV-6 infection, whereas HM pretreated with human recombinant IL-15 showed an increased permissiveness for HHV-6 infection [6].

High impact information on Herpesvirus 6, Human

  • CD46 is a cellular receptor for human herpesvirus 6 [7].
  • Given the ubiquitous nature of this virus and the challenging precedent of correlating antiviral antibodies with disease association, these antibody studies have been supported by the detection of HHV-6 DNA from samples of MS serum as a marker of active viral infection [1].
  • In addition to fresh T cells, HBLV was able to infect normal T lymphocytes expanded in vitro with IL-2 for greater than 30 d [8].
  • IL-15 protein synthesis was increased in response to HHV-6 [9].
  • Furthermore, NK activation by HHV-6 was blocked with mAb to CD122, as well as by human anti-HHV-6 neutralizing antibodies [9].

Chemical compound and disease context of Herpesvirus 6, Human


Biological context of Herpesvirus 6, Human

  • Downregulation of surface CD46 was documented during the course of HHV-6 infection [7].
  • These findings are consistent with the hypothesis that the U94 gene product of HHV-6 regulates viral gene expression and enables the establishment and/or maintenance of latent infection in lymphoid cells [15].
  • Two sensitive polymerase chain reaction assays were used to target different regions within the HHV-6 genome [16].
  • During the course of HHV-6 infection, analysis of the surface membrane phenotype of the T cell populations and clones revealed a progressive decline in the expression of the CD3/TCR complex, whereas other T cell-associated markers (e.g., CD2) were unaffected [13].
  • We employed a quantitative cell fusion assay to identify structural domains of CD46 required for its function as a receptor for human herpesvirus 6 (HHV-6) [17].

Anatomical context of Herpesvirus 6, Human


Gene context of Herpesvirus 6, Human


Analytical, diagnostic and therapeutic context of Herpesvirus 6, Human

  • Purified immature DC (derived from adherent peripheral blood mononuclear cells in the presence of granulocyte-macrophage colony-stimulating factor and interleukin-4) could be infected with HHV-6, as determined by PCR analyses, intracellular monoclonal antibody staining, and presence of virus in culture supernatants [28].
  • In dual immunofluorescence assays, the infected cells were detected by antibodies against the HHV-6 p41 nuclear antigen and glial fibrillary acidic protein, indicating that the infected cells are indeed astrocytes [29].
  • Immunohistochemistry using an antibody raised against the HHV-6 rep gene product (REP) revealed that REP was mainly present in the nucleus of MT-4 cells within 24 h after infection with HHV-6B [30].
  • The recombinant protein expressed from the entire HHV-6 MCP gene was detected only weakly in Western blot assays with normal HHV-6-positive human sera as a probe [31].
  • Flow cytometry and Scatchard analysis of TNF receptors revealed an increase in the number of the p55 form of TNF receptors on JJHAN cells after HHV-6 inoculation [32].


  1. Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA. Soldan, S.S., Berti, R., Salem, N., Secchiero, P., Flamand, L., Calabresi, P.A., Brennan, M.B., Maloni, H.W., McFarland, H.F., Lin, H.C., Patnaik, M., Jacobson, S. Nat. Med. (1997) [Pubmed]
  2. Human herpes virus-6 increases HIV-1 expression in co-infected T cells via nuclear factors binding to the HIV-1 enhancer. Ensoli, B., Lusso, P., Schachter, F., Josephs, S.F., Rappaport, J., Negro, F., Gallo, R.C., Wong-Staal, F. EMBO J. (1989) [Pubmed]
  3. CD68+ cells of monocyte/macrophage lineage in the environment of AIDS-associated and classic-sporadic Kaposi sarcoma are singly or doubly infected with human herpesviruses 7 and 6B. Kempf, W., Adams, V., Wey, N., Moos, R., Schmid, M., Avitabile, E., Campadelli-Fiume, G. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  4. Cross-reactivity with myelin basic protein and human herpesvirus-6 in multiple sclerosis. Tejada-Simon, M.V., Zang, Y.C., Hong, J., Rivera, V.M., Zhang, J.Z. Ann. Neurol. (2003) [Pubmed]
  5. Human herpesvirus 6 and Epstein-Barr virus in Hodgkin's disease: a controlled study by polymerase chain reaction and in situ hybridization. Valente, G., Secchiero, P., Lusso, P., Abete, M.C., Jemma, C., Reato, G., Kerim, S., Gallo, R.C., Palestro, G. Am. J. Pathol. (1996) [Pubmed]
  6. Role of IL-15 on monocytic resistance to human herpesvirus 6 infection. Arena, A., Merendino, R.A., Bonina, L., Iannello, D., Stassi, G., Mastroeni, P. New Microbiol. (2000) [Pubmed]
  7. CD46 is a cellular receptor for human herpesvirus 6. Santoro, F., Kennedy, P.E., Locatelli, G., Malnati, M.S., Berger, E.A., Lusso, P. Cell (1999) [Pubmed]
  8. In vitro cellular tropism of human B-lymphotropic virus (human herpesvirus-6). Lusso, P., Markham, P.D., Tschachler, E., di Marzo Veronese, F., Salahuddin, S.Z., Ablashi, D.V., Pahwa, S., Krohn, K., Gallo, R.C. J. Exp. Med. (1988) [Pubmed]
  9. Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15. Flamand, L., Stefanescu, I., Menezes, J. J. Clin. Invest. (1996) [Pubmed]
  10. Susceptibility of human herpesvirus 6 to acyclovir and ganciclovir. Russler, S.K., Tapper, M.A., Carrigan, D.R. Lancet (1989) [Pubmed]
  11. Susceptibility of human herpesvirus 6 to acyclovir. Kikuta, H., Lu, H., Matsumoto, S. Lancet (1989) [Pubmed]
  12. Selective suppression of IL-12 production by human herpesvirus 6. Smith, A., Santoro, F., Di Lullo, G., Dagna, L., Verani, A., Lusso, P. Blood (2003) [Pubmed]
  13. Productive infection of CD4+ and CD8+ mature human T cell populations and clones by human herpesvirus 6. Transcriptional down-regulation of CD3. Lusso, P., Malnati, M., De Maria, A., Balotta, C., DeRocco, S.E., Markham, P.D., Gallo, R.C. J. Immunol. (1991) [Pubmed]
  14. Activation of monocyte cyclooxygenase-2 gene expression by human herpesvirus 6. Role for cyclic AMP-responsive element-binding protein and activator protein-1. Janelle, M.E., Gravel, A., Gosselin, J., Tremblay, M.J., Flamand, L. J. Biol. Chem. (2002) [Pubmed]
  15. U94 of human herpesvirus 6 is expressed in latently infected peripheral blood mononuclear cells and blocks viral gene expression in transformed lymphocytes in culture. Rotola, A., Ravaioli, T., Gonelli, A., Dewhurst, S., Cassai, E., Di Luca, D. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  16. Infrequent detection of human herpesvirus 6 DNA in peripheral blood mononuclear cells from multiple sclerosis patients. Mayne, M., Krishnan, J., Metz, L., Nath, A., Auty, A., Sahai, B.M., Power, C. Ann. Neurol. (1998) [Pubmed]
  17. Human Herpesvirus 6 and Measles Virus Employ Distinct CD46 Domains for Receptor Function. Greenstone, H.L., Santoro, F., Lusso, P., Berger, E.A. J. Biol. Chem. (2002) [Pubmed]
  18. A chronic illness characterized by fatigue, neurologic and immunologic disorders, and active human herpesvirus type 6 infection. Buchwald, D., Cheney, P.R., Peterson, D.L., Henry, B., Wormsley, S.B., Geiger, A., Ablashi, D.V., Salahuddin, S.Z., Saxinger, C., Biddle, R. Ann. Intern. Med. (1992) [Pubmed]
  19. Latent infection and reactivation of human herpesvirus 6 in two novel myeloid cell lines. Yasukawa, M., Ohminami, H., Sada, E., Yakushijin, Y., Kaneko, M., Yanagisawa, K., Kohno, H., Bando, S., Fujita, S. Blood (1999) [Pubmed]
  20. Enhancement of natural killer cell cytotoxicity by the human herpesvirus-7 via IL-15 induction. Atedzoe, B.N., Ahmad, A., Menezes, J. J. Immunol. (1997) [Pubmed]
  21. Detection of human herpesvirus 6 and human papillomavirus 16 in cervical carcinoma. Chen, M., Wang, H., Woodworth, C.D., Lusso, P., Berneman, Z., Kingma, D., Delgado, G., DiPaolo, J.A. Am. J. Pathol. (1994) [Pubmed]
  22. Cell lines containing and expressing the human herpesvirus 6A ts gene are protected from both H-ras and BPV-1 transformation. Araujo, J.C., Doniger, J., Stöppler, H., Sadaie, M.R., Rosenthal, L.J. Oncogene (1997) [Pubmed]
  23. RANTES binding and down-regulation by a novel human herpesvirus-6 beta chemokine receptor. Milne, R.S., Mattick, C., Nicholson, L., Devaraj, P., Alcami, A., Gompels, U.A. J. Immunol. (2000) [Pubmed]
  24. Identification and characterization of U83A viral chemokine, a broad and potent beta-chemokine agonist for human CCRs with unique selectivity and inhibition by spliced isoform. Dewin, D.R., Catusse, J., Gompels, U.A. J. Immunol. (2006) [Pubmed]
  25. Down-regulation of CXCR4 by human herpesvirus 6 (HHV-6) and HHV-7. Yasukawa, M., Hasegawa, A., Sakai, I., Ohminami, H., Arai, J., Kaneko, S., Yakushijin, Y., Maeyama, K., Nakashima, H., Arakaki, R., Fujita, S. J. Immunol. (1999) [Pubmed]
  26. A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6. Lüttichau, H.R., Clark-Lewis, I., Jensen, P.Ø., Moser, C., Gerstoft, J., Schwartz, T.W. J. Biol. Chem. (2003) [Pubmed]
  27. Complete DNA sequence of the rat cytomegalovirus genome. Vink, C., Beuken, E., Bruggeman, C.A. J. Virol. (2000) [Pubmed]
  28. Human herpesvirus 6 infects dendritic cells and suppresses human immunodeficiency virus type 1 replication in coinfected cultures. Asada, H., Klaus-Kovtun, V., Golding, H., Katz, S.I., Blauvelt, A. J. Virol. (1999) [Pubmed]
  29. Infection of primary human fetal astrocytes by human herpesvirus 6. He, J., McCarthy, M., Zhou, Y., Chandran, B., Wood, C. J. Virol. (1996) [Pubmed]
  30. Expression of human herpesvirus 6B rep within infected cells and binding of its gene product to the TATA-binding protein in vitro and in vivo. Mori, Y., Dhepakson, P., Shimamoto, T., Ueda, K., Gomi, Y., Tani, H., Matsuura, Y., Yamanishi, K. J. Virol. (2000) [Pubmed]
  31. Identification, cloning, and expression of the major capsid protein gene of human herpesvirus 6. Littler, E., Lawrence, G., Liu, M.Y., Barrell, B.G., Arrand, J.R. J. Virol. (1990) [Pubmed]
  32. Induction of T-cell apoptosis by human herpesvirus 6. Inoue, Y., Yasukawa, M., Fujita, S. J. Virol. (1997) [Pubmed]
WikiGenes - Universities