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MeSH Review

Herpesvirus 7, Human

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Disease relevance of Herpesvirus 7, Human

  • The antibodies are specific for HHV-7 and HHV-6B, respectively, and they retained reactivity for antigens contained in formalin-fixed, paraffin-embedded tissue samples [1].
  • HHV- 6 contains two genes (U12 and U51) that encode putative homologs of cellular G-protein-coupled receptors (GCR), while three other betaherpesviruses, human cytomegalovirus, murine cytomegalovirus, and human herpesvirus 7, have three, one, and two GCR-homologous genes, respectively [2].
  • On the basis of the analyses of sera from children and adults it can be concluded that HHV-7 is a prevalent human herpesvirus which, like other human herpesviruses, infects during childhood [3].
  • It was recently suggested that the CXC chemokine receptor 4 (CXCR4), which was found to be a crucial coreceptor for T-tropic HIV-1 strains, may also play a role in the HHV-7 infection process [4].
  • The study of distinct HHV-7-positive human samples showed preferential associations of some gB alleles with some alleles of two other genes, distantly located on the HHV-7 genome, coding for the phosphoprotein p100 (p100) and the major capsid protein (MCP) [5].

High impact information on Herpesvirus 7, Human


Chemical compound and disease context of Herpesvirus 7, Human


Biological context of Herpesvirus 7, Human


Anatomical context of Herpesvirus 7, Human


Gene context of Herpesvirus 7, Human

  • On the other hand, HHV-7 did not affect IL-4 and IL-6 synthesis [21].
  • The HHV-7 infection also significantly (P < 0.05) decreased the production of IL-2 from activated, IL-2-producing PBMC [21].
  • U94/REP inhibited the replication of other betaherpesviruses, HHV-7 and human cytomegalovirus, but had no effect on herpes simplex virus [22].
  • There were quantitative differences in the activation of p53, Bax, p21WAF and Bcl-2 in HHV 6-infected CBC as compared to HHV-7 infection supporting the apoptosis cycle [23].
  • Moreover, HHV-6, but not the closely related betaherpesvirus HHV-7, dramatically suppressed the secretion of interleukin-12 (IL-12) p70 by DC, while the production of other cytokines that influence DC maturation, i.e., IL-10 and tumor necrosis factor alpha, was not significantly modified [24].

Analytical, diagnostic and therapeutic context of Herpesvirus 7, Human


  1. CD68+ cells of monocyte/macrophage lineage in the environment of AIDS-associated and classic-sporadic Kaposi sarcoma are singly or doubly infected with human herpesviruses 7 and 6B. Kempf, W., Adams, V., Wey, N., Moos, R., Schmid, M., Avitabile, E., Campadelli-Fiume, G. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Human herpesvirus 6 open reading frame U12 encodes a functional beta-chemokine receptor. Isegawa, Y., Ping, Z., Nakano, K., Sugimoto, N., Yamanishi, K. J. Virol. (1998) [Pubmed]
  3. Human herpesvirus 7: antigenic properties and prevalence in children and adults. Wyatt, L.S., Rodriguez, W.J., Balachandran, N., Frenkel, N. J. Virol. (1991) [Pubmed]
  4. CXC-chemokine receptor 4 is not a coreceptor for human herpesvirus 7 entry into CD4(+) T cells. Zhang, Y., Hatse, S., De Clercq, E., Schols, D. J. Virol. (2000) [Pubmed]
  5. Preferential associations of alleles of three distinct genes argue for the existence of two prototype variants of human herpesvirus 7. Franti, M., Aubin, J.T., Gautheret-Dejean, A., Malet, I., Cahour, A., Huraux, J.M., Agut, H. J. Virol. (1999) [Pubmed]
  6. CD4 is a critical component of the receptor for human herpesvirus 7: interference with human immunodeficiency virus. Lusso, P., Secchiero, P., Crowley, R.W., Garzino-Demo, A., Berneman, Z.N., Gallo, R.C. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  7. Human herpesvirus 7 induces the functional up-regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) coupled to TRAIL-R1 down-modulation in CD4(+) T cells. Secchiero, P., Mirandola, P., Zella, D., Celeghini, C., Gonelli, A., Vitale, M., Capitani, S., Zauli, G. Blood (2001) [Pubmed]
  8. Infection of CD34(+) hematopoietic progenitor cells by human herpesvirus 7 (HHV-7). Mirandola, P., Secchiero, P., Pierpaoli, S., Visani, G., Zamai, L., Vitale, M., Capitani, S., Zauli, G. Blood (2000) [Pubmed]
  9. Progressive and persistent downregulation of surface CXCR4 in CD4(+) T cells infected with human herpesvirus 7. Secchiero, P., Zella, D., Barabitskaja, O., Reitz, M.S., Capitani, S., Gallo, R.C., Zauli, G. Blood (1998) [Pubmed]
  10. Human Herpesvirus 7 induces CD4(+) T-cell death by two distinct mechanisms: necrotic lysis in productively infected cells and apoptosis in uninfected or nonproductively infected cells. Secchiero, P., Flamand, L., Gibellini, D., Falcieri, E., Robuffo, I., Capitani, S., Gallo, R.C., Zauli, G. Blood (1997) [Pubmed]
  11. Antiviral agents active against human herpesviruses HHV-6, HHV-7 and HHV-8. De Clercq, E., Naesens, L., De Bolle, L., Schols, D., Zhang, Y., Neyts, J. Rev. Med. Virol. (2001) [Pubmed]
  12. Role of the extracellular domain of human herpesvirus 7 glycoprotein B in virus binding to cell surface heparan sulfate proteoglycans. Secchiero, P., Sun, D., De Vico, A.L., Crowley, R.W., Reitz, M.S., Zauli, G., Lusso, P., Gallo, R.C. J. Virol. (1997) [Pubmed]
  13. Identification and analysis of a novel heparin-binding glycoprotein encoded by human herpesvirus 7. Skrincosky, D., Hocknell, P., Whetter, L., Secchiero, P., Chandran, B., Dewhurst, S. J. Virol. (2000) [Pubmed]
  14. Identification of human telomeric repeat motifs at the genome termini of human herpesvirus 7: structural analysis and heterogeneity. Secchiero, P., Nicholas, J., Deng, H., Xiaopeng, T., van Loon, N., Ruvolo, V.R., Berneman, Z.N., Reitz, M.S., Dewhurst, S. J. Virol. (1995) [Pubmed]
  15. A human herpesvirus 7 glycoprotein, U21, diverts major histocompatibility complex class I molecules to lysosomes. Hudson, A.W., Howley, P.M., Ploegh, H.L. J. Virol. (2001) [Pubmed]
  16. The 85-kilodalton phosphoprotein (pp85) of human herpesvirus 7 is encoded by open reading frame U14 and localizes to a tegument substructure in virion particles. Stefan, A., Secchiero, P., Baechi, T., Kempf, W., Campadelli-Fiume, G. J. Virol. (1997) [Pubmed]
  17. Herpesvirus infections in solid organ transplant patients at high risk of primary cytomegalovirus disease. Razonable, R.R., Brown, R.A., Humar, A., Covington, E., Alecock, E., Paya, C.V. J. Infect. Dis. (2005) [Pubmed]
  18. Down-regulation of human leukocyte antigen class I and II and beta 2-microglobulin expression in human herpesvirus-7-infected cells. Mirandola, P., Sponzilli, I., Solenghi, E., Micheloni, C., Rinaldi, L., Gobbi, G., Vitale, M. J. Infect. Dis. (2006) [Pubmed]
  19. Human herpesvirus (HHV)-6 and HHV-7: two closely related viruses with different infection profiles in stem cell transplantation recipients. Boutolleau, D., Fernandez, C., André, E., Imbert-Marcille, B.M., Milpied, N., Agut, H., Gautheret-Dejean, A. J. Infect. Dis. (2003) [Pubmed]
  20. Immunohistochemical assessment of fractalkine, inflammatory cells, and human herpesvirus 7 in human salivary glands. Latchney, L.R., Fallon, M.A., Culp, D.J., Gelbard, H.A., Dewhurst, S. J. Histochem. Cytochem. (2004) [Pubmed]
  21. Modulatory effects of human herpes virus-7 on cytokine synthesis and cell proliferation in human peripheral blood mononuclear cell cultures. Atedzoé, B.N., Menezes, J., D'Addario, M., Xu, J., Ongradi, J., Ahmad, A. J. Leukoc. Biol. (1999) [Pubmed]
  22. Human herpesvirus 6 (HHV-6) U94/REP protein inhibits betaherpesvirus replication. Caselli, E., Bracci, A., Galvan, M., Boni, M., Rotola, A., Bergamini, C., Cermelli, C., Dal Monte, P., Gompels, U.A., Cassai, E., Di Luca, D. Virology (2006) [Pubmed]
  23. In vitro cytobiological effects of human herpesviruses 6 and 7: immunohistological monitoring of apoptosis, differentiation and cell proliferation. Kirn, E., Krueger, E., Boehmer, S., Klussmann, J.P., Krueger, G.R. Anticancer Res. (1997) [Pubmed]
  24. Viral replication-independent blockade of dendritic cell maturation and interleukin-12 production by human herpesvirus 6. Smith, A.P., Paolucci, C., Di Lullo, G., Burastero, S.E., Santoro, F., Lusso, P. J. Virol. (2005) [Pubmed]
  25. Prospective study of human betaherpesviruses after renal transplantation: association of human herpesvirus 7 and cytomegalovirus co-infection with cytomegalovirus disease and increased rejection. Kidd, I.M., Clark, D.A., Sabin, C.A., Andrew, D., Hassan-Walker, A.F., Sweny, P., Griffiths, P.D., Emery, V.C. Transplantation (2000) [Pubmed]
  26. Human herpesvirus 7: another causal agent for roseola (exanthem subitum). Tanaka, K., Kondo, T., Torigoe, S., Okada, S., Mukai, T., Yamanishi, K. J. Pediatr. (1994) [Pubmed]
  27. Prevalence and distribution of human herpesvirus 7 in normal brain. Chan, P.K., Ng, H.K., Cheung, J.L., Ng, K.C., Cheng, A.F. J. Med. Virol. (2000) [Pubmed]
  28. Human herpesvirus type 7 in Hodgkin's disease. Secchiero, P., Bonino, L.D., Lusso, P., Abele, M.C., Reato, G., Kerim, S., Palestro, G., Zauli, G., Valente, G. Br. J. Haematol. (1998) [Pubmed]
  29. Correlation between the detection of viral DNA by the polymerase chain reaction in peripheral blood leukocytes and serological responses to human herpesvirus 6, human herpesvirus 7, and cytomegalovirus in renal allograft recipients. Osman, H.K., Peiris, J.S., Taylor, C.E., Karlberg, J.P., Madeley, C.R. J. Med. Virol. (1997) [Pubmed]
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