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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Sep1  -  Septin 1

Drosophila melanogaster

Synonyms: 38960, CG1403, DIFF6 protein homolog, Diff6, Dmel\CG1403, ...
 
 
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High impact information on Sep1

  • Examination of two other septins showed that Sep1 was not detectable at the cellularization front in the Pnut-deficient embryos, whereas Sep2 was still present in normal levels [1].
  • Both immunolocalization and biochemical experiments show that Sep1 is intimately associated with Pnut, suggesting that the Drosophila septins, like those in yeast, function as part of a complex [2].
  • We have isolated the cDNA corresponding to this DRES and show that it is a novel member of the family of septin genes, which encode proteins with GTPase activity thought to interact during cytokinesis [3].

References

  1. Evidence for functional differentiation among Drosophila septins in cytokinesis and cellularization. Adam, J.C., Pringle, J.R., Peifer, M. Mol. Biol. Cell (2000) [Pubmed]
  2. Localization and possible functions of Drosophila septins. Fares, H., Peifer, M., Pringle, J.R. Mol. Biol. Cell (1995) [Pubmed]
  3. A human gene similar to Drosophila melanogaster peanut maps to the DiGeorge syndrome region of 22q11. McKie, J.M., Sutherland, H.F., Harvey, E., Kim, U.J., Scambler, P.J. Hum. Genet. (1997) [Pubmed]
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