The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

pnut  -  peanut

Drosophila melanogaster

Synonyms: CG8705, Dmel\CG8705, E(sina)44C, E(sina)8, PNUT, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on pnut

  • ARTS is an unusual septin-like mitochondrial protein that was originally shown to mediate TGF-beta-induced apoptosis [1].
  • A two-hybrid screen revealed that Orc6 interacts with the Drosophila peanut (pnut), a member of the septin family of proteins important for cell division [2].
  • The majority of the Saccharomyces cerevisiae septin complexes do not exchange guanine nucleotides [3].
  • Both immunolocalization and biochemical experiments show that Sep1 is intimately associated with Pnut, suggesting that the Drosophila septins, like those in yeast, function as part of a complex [4].
  • Based on these results we propose that D-hil may function as a regulator of septin function during cytokinesis in the developing nervous system [5].

Biological context of pnut

  • However, by creating double mutant flies we show that the D-hil locus acts as a modulator of Pnut function by increasing the level of polyploidy of neuroblasts in Pnut(KG00478)/Pnut(KG00478) larval brains [5].


  1. The mitochondrial ARTS protein promotes apoptosis through targeting XIAP. Gottfried, Y., Rotem, A., Lotan, R., Steller, H., Larisch, S. EMBO J. (2004) [Pubmed]
  2. A cytokinetic function of Drosophila ORC6 protein resides in a domain distinct from its replication activity. Chesnokov, I.N., Chesnokova, O.N., Botchan, M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. The majority of the Saccharomyces cerevisiae septin complexes do not exchange guanine nucleotides. Vrabioiu, A.M., Gerber, S.A., Gygi, S.P., Field, C.M., Mitchison, T.J. J. Biol. Chem. (2004) [Pubmed]
  4. Localization and possible functions of Drosophila septins. Fares, H., Peifer, M., Pringle, J.R. Mol. Biol. Cell (1995) [Pubmed]
  5. D-Hillarin, a novel W180-domain protein, affects cytokinesis through interaction with the septin family member Pnut. Ji, Y., Rath, U., Girton, J., Johansen, K.M., Johansen, J. J. Neurobiol. (2005) [Pubmed]
WikiGenes - Universities