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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

pnut  -  peanut

Drosophila melanogaster

Synonyms: CG8705, Dmel\CG8705, E(sina)44C, E(sina)8, PNUT, ...
 
 
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High impact information on pnut

  • ARTS is an unusual septin-like mitochondrial protein that was originally shown to mediate TGF-beta-induced apoptosis [1].
  • A two-hybrid screen revealed that Orc6 interacts with the Drosophila peanut (pnut), a member of the septin family of proteins important for cell division [2].
  • The majority of the Saccharomyces cerevisiae septin complexes do not exchange guanine nucleotides [3].
  • Both immunolocalization and biochemical experiments show that Sep1 is intimately associated with Pnut, suggesting that the Drosophila septins, like those in yeast, function as part of a complex [4].
  • Based on these results we propose that D-hil may function as a regulator of septin function during cytokinesis in the developing nervous system [5].
 

Biological context of pnut

  • However, by creating double mutant flies we show that the D-hil locus acts as a modulator of Pnut function by increasing the level of polyploidy of neuroblasts in Pnut(KG00478)/Pnut(KG00478) larval brains [5].

References

  1. The mitochondrial ARTS protein promotes apoptosis through targeting XIAP. Gottfried, Y., Rotem, A., Lotan, R., Steller, H., Larisch, S. EMBO J. (2004) [Pubmed]
  2. A cytokinetic function of Drosophila ORC6 protein resides in a domain distinct from its replication activity. Chesnokov, I.N., Chesnokova, O.N., Botchan, M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. The majority of the Saccharomyces cerevisiae septin complexes do not exchange guanine nucleotides. Vrabioiu, A.M., Gerber, S.A., Gygi, S.P., Field, C.M., Mitchison, T.J. J. Biol. Chem. (2004) [Pubmed]
  4. Localization and possible functions of Drosophila septins. Fares, H., Peifer, M., Pringle, J.R. Mol. Biol. Cell (1995) [Pubmed]
  5. D-Hillarin, a novel W180-domain protein, affects cytokinesis through interaction with the septin family member Pnut. Ji, Y., Rath, U., Girton, J., Johansen, K.M., Johansen, J. J. Neurobiol. (2005) [Pubmed]
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