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Gene Review:

murC - UDP-N-acetylmuramate--L-alanine ligase

Corynebacterium glutamicum ATCC 13032

Ramos, A. et al.

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Disease relevance of murC

Characterization and chromosomal organization of the murD-murC-ftsQ region of Corynebacterium glutamicum ATCC 13869 [1].

High impact information on murC

Disruption experiments performed in C. glutamicum using internal fragments of the ftsW, murG and murC genes allowed us to conclude that FtsW, MurG, and MurC are essential gene products in C. glutamicum [1].
Dicistronic (ftsQ-ftsZ) and monocistronic (murC and ftsZ) transcripts can be detected using specific probes and are in agreement with the lack of transcriptional terminators in the partially analysed dcw cluster [1].
The murC gene product was purified to near homogeneity and its UDP-N-acetylmuramate: L-alanine adding activity was demonstrated [1].

References

Characterization and chromosomal organization of the murD-murC-ftsQ region of Corynebacterium glutamicum ATCC 13869. Ramos, A., Honrubia, M.P., Vega, D., Ayala, J.A., Bouhss, A., Mengin-Lecreulx, D., Gil, J.A. Res. Microbiol. (2004) [Pubmed]

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