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Chemical Compound Review

uridine diphosphate N-acetylmuramic acid     2-[3-acetamido-2-[[[5-(2,4- dioxopyrimidin...

Synonyms: HMDB11720, AC1L1AVQ, N-acetylmuramoyl-UDP, UDP-N-acetylmuramate, UDP-N-acetylmuraminate, ...
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Disease relevance of uridine diphosphate N-acetylmuramic acid


High impact information on uridine diphosphate N-acetylmuramic acid

  • This enzyme is responsible for the synthesis of UDP-N-acetylmuramic acid in bacterial cell wall biosynthesis and consequently provides an attractive target for the design of antibacterial agents [4].
  • Mutations K130A, H199A, N293A, N296A, and R327A led to important variations of the Km values for one or more substrates, thereby indicating that these residues are involved in the structure of the active site and suggesting that the binding order of the substrates could be ATP, UDP-MurNAc, and alanine [5].
  • Identification of the mpl gene encoding UDP-N-acetylmuramate: L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase in Escherichia coli and its role in recycling of cell wall peptidoglycan [6].
  • The acetyltransferase activity is greatly inhibited by its reaction product N-acetylglucosamine-1-phosphate and, interestingly, also by UDP-N-acetylmuramic acid, which is one of the first precursors specific for the peptidoglycan pathway [7].
  • The biochemical basis for the acquired or natural resistance of various gram-positive organisms to glycopeptides was studied by high-pressure liquid chromatographic analysis of their peptidoglycan UDP-MurNAc-peptide precursors [8].

Chemical compound and disease context of uridine diphosphate N-acetylmuramic acid


Gene context of uridine diphosphate N-acetylmuramic acid

  • These results indicate that both the relA gene product and feedback inhibition are involved in regulating UDP-MurNAc-peptide synthesis during amino acid deprivation [10].

Analytical, diagnostic and therapeutic context of uridine diphosphate N-acetylmuramic acid


  1. Kinetic and mechanistic characterization of recombinant Lactobacillus viridescens FemX (UDP-N-acetylmuramoyl pentapeptide-lysine N6-alanyltransferase). Hegde, S.S., Blanchard, J.S. J. Biol. Chem. (2003) [Pubmed]
  2. Identification of the namH gene, encoding the hydroxylase responsible for the N-glycolylation of the mycobacterial peptidoglycan. Raymond, J.B., Mahapatra, S., Crick, D.C., Pavelka, M.S. J. Biol. Chem. (2005) [Pubmed]
  3. Biochemical evidence for the formation of a covalent acyl-phosphate linkage between UDP-N-acetylmuramate and ATP in the Escherichia coli UDP-N-acetylmuramate:L-alanine ligase-catalyzed reaction. Falk, P.J., Ervin, K.M., Volk, K.S., Ho, H.T. Biochemistry (1996) [Pubmed]
  4. An enzyme-substrate complex involved in bacterial cell wall biosynthesis. Benson, T.E., Filman, D.J., Walsh, C.T., Hogle, J.M. Nat. Struct. Biol. (1995) [Pubmed]
  5. Invariant amino acids in the Mur peptide synthetases of bacterial peptidoglycan synthesis and their modification by site-directed mutagenesis in the UDP-MurNAc:L-alanine ligase from Escherichia coli. Bouhss, A., Mengin-Lecreulx, D., Blanot, D., van Heijenoort, J., Parquet, C. Biochemistry (1997) [Pubmed]
  6. Identification of the mpl gene encoding UDP-N-acetylmuramate: L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase in Escherichia coli and its role in recycling of cell wall peptidoglycan. Mengin-Lecreulx, D., van Heijenoort, J., Park, J.T. J. Bacteriol. (1996) [Pubmed]
  7. Copurification of glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase activities of Escherichia coli: characterization of the glmU gene product as a bifunctional enzyme catalyzing two subsequent steps in the pathway for UDP-N-acetylglucosamine synthesis. Mengin-Lecreulx, D., van Heijenoort, J. J. Bacteriol. (1994) [Pubmed]
  8. Modification of peptidoglycan precursors is a common feature of the low-level vancomycin-resistant VANB-type Enterococcus D366 and of the naturally glycopeptide-resistant species Lactobacillus casei, Pediococcus pentosaceus, Leuconostoc mesenteroides, and Enterococcus gallinarum. Billot-Klein, D., Gutmann, L., Sablé, S., Guittet, E., van Heijenoort, J. J. Bacteriol. (1994) [Pubmed]
  9. A method for the enzymatic synthesis and HPLC purification of the peptidoglycan precursor UDP-N-acetylmuramic acid. Raymond, J.B., Price, N.P., Pavelka, M.S. FEMS Microbiol. Lett. (2003) [Pubmed]
  10. Involvement of the relA gene product and feedback inhibition in the regulation of DUP-N-acetylmuramyl-peptide synthesis in Escherichia coli. Ishiguro, E.E., Ramey, W.D. J. Bacteriol. (1978) [Pubmed]
  11. UDP-N-acetylmuramic acid (UDP-MurNAc) is a potent inhibitor of MurA (enolpyruvyl-UDP-GlcNAc synthase). Mizyed, S., Oddone, A., Byczynski, B., Hughes, D.W., Berti, P.J. Biochemistry (2005) [Pubmed]
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